Glutathione S-transferases (GSTs) exist in various eukaryotes and function in detoxification of xenobiotics and in response to abiotic and biotic stresses. We have carried out a genome-wide survey of this gene family in 10 plant genomes. Our data show that tandem duplication has been regarded as the major expansion mechanism and both monocot and dicot plants may have practiced different expansi...

The ligandin activity of specific glutathione S-transferases (GSTs) is necessary for the transport of anthocyanins from the cytosol to the plant vacuole. Five GSTs were purified from Vitis vinifera L. cv. Gamay Fréaux cell suspension cultures by glutathione affinity chromatography. These proteins underwent Edman sequencing and mass spectrometry fingerprinting, with the resultant fragments align...

Objectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in Western world. detected an advanced stage disease approximately 80% patients. Glutathione S-transferases (GSTs) important family involved detoxification several xenobiotics. Thus, this mechanism protects tissues from harmful effects oxidative stress and chemical-induced damages....

The presence of glutathione transferases and esterase activity was investigated in Rhopalosiphum padi and the effects of the cereal hydroxamic acid, 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) on these detoxification enzymes was studied. Activity of glutathione S-transferases and general esterases was determined for adult aphids feeding on a natural diet lacking DIMBOA and on an artif...

Glutathione S-transferases (GSTs) play an important role in the detoxification of diverse electrophilic chemicals, including anticancer drugs. Gene-specific Oligonucleotide probes were developed to monitor the expression of individual GST mRNAs in livers of adult male rats treated with drugs and other chemical modulators of GST expression. Northern blot analysis of total liver RNA using probes ...

Glutathione S-transferases (GSTs) are a major family of detoxification enzymes which possess a wide range of substrate specificities. Interest in insect GSTs has primarily focused on their role in insecticide resistance. In this study, following World Health Organization (WHO) routine susceptibility test, DNA was extracted from specimens of Anopheles stephensi collected from the Kazeroon distri...

background: endometriosis influenced by both genetic and environmental factors. associations of glutathione s-transferases (gsts) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.objective: we examined the associations of gstm1 and gstt1 null genotypes and gstp1 313 a/g polymorphisms with endometriosis in an iranian popu...

Glutathione S-transferases (GSTs; EC 2.5.1.18) are a multigene family of dimeric multifunctional proteins that play a central role in detoxication of xenobiotic compounds including drugs, herbicides and insecticides [ 11. Based on extensively characterized physicochemical and immunological properties, the mammalian GSTs have been grouped into at least four distinct classes: Alpha, Mu, Pi and Th...

The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. In animals, enhanced expression is mediated by products of gut fermentation. Of these, butyrate induces GSTP1 protein expression and GST activity in the human colon tumor cell line HT29. The aim of the following investigations was to further elucidate butyrate-modulated i...

The Kappa class of GSTs (glutathione transferases) comprises soluble enzymes originally isolated from the mitochondrial matrix of rats. We have characterized a Kappa class cDNA from human breast. The cDNA is derived from a single gene comprising eight exons and seven introns located on chromosome 7q34-35. Recombinant hGSTK1-1 was expressed in Escherichia coli as a homodimer (subunit molecular m...