BACKGROUND Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that has been responsible for a number of large-scale epidemics as well as imported cases covering a wide geographical range. As a blood-borne virus capable of mounting a high-titer viremia in infected humans, CHIKV was included on a list of risk agents for transfusion and organ transplant by the AABB Transfusion-Transmit...

Since blood is a biologic product, it is unlikely that the risk for transfusion-transmitted infection will ever be reduced to zero. The approach to emerging infections associated with transfusion of blood and blood products includes assessing the transmissibility of the agent by this route; developing effective prevention strategies, including screening tests and donor deferral policies; improv...

As the risks of allogeneic blood transfusion (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic transfusion reactions (HTRs), and transfusion-associated sepsis (TAS) emerged as the leading causes of ABT-related deaths. Since 2004, preventive measures for TRALI and TAS have been implemented, but their implementatio...

Transfusion of blood products can lead to various transfusion reactions. Transfusion reactions that can cause pulmonary complications are: circulatory overload, anaphylactic reactions, bacterial contamination and transfusion-related acute lung injury (TRALI). TRALI is a rare but life-threatening complication of transfusion. TRALI is now the leading cause of transfusion-related fatalities report...

Hepatitis E virus (HEV) which is mainly transmitted through faecal-oral route, can also be transmitted via parenteral and vertical route. Recent studies suggest zoonotic nature of the virus. The last studies done in Turkey indicate increasing frequency of HEV infection. This study was conducted to determine the rate of anti-HEV seropositivity among patients with terminal stage renal failure und...

BACKGROUND Blood transfusion safety commences with healthy donor recruitment. The threat of transfusion transmitted infections is greatly minimized by serological tools but not entirely eliminated. Recently, nucleic-acid testing for blood donor screening has virtually eliminated this jeopardy. METHODS This prospective study was conducted from February 2015 to February 2016. Samples from seron...

Although blood transfusion can be lifesaving, it involves risks such as transfusion-transmitted infections (TTIs). In late 2003 in Korea, 4 units of human immunodeficiency virus (HIV)-infected blood were transfused to recipients during the window period. At that time, it was also disclosed that many unqualified blood products had been supplied to hospitals [1]. These serious incidents prompted ...

BACKGROUND Estimates for human immunodeficiency virus (HIV)-1 and hepatitis C virus (HCV) transfusion-transmitted risks have relied on incidence derived from repeat donor histories and imprecise estimates for infectious, preseroconversion window periods (WPs). STUDY DESIGN AND METHODS By use of novel approaches, WPs were estimated by back-extrapolation of acute viral replication dynamics. Inc...