Conduction at the Purkinje-ventricular junction (PVJ) demonstrates unidirectional block under both physiological and pathophysiological conditions. Although this block is typically attributed to multidimensional electrotonic interactions, we examined possible membrane-level contributions using single, isolated rabbit Purkinje (P) and ventricular (V) myocytes coupled by an electronic circuit. Wh...

OBJECTIVES The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in a model of healed myocardial infarction. BACKGROUND Post-infarction ventricular arrhythmias frequently cause sudden death. Impaired myocardial conduction has previously been linked to ventricular arrhythmias. Altered connexin expressio...

A modification to the smoothed particle hydrodynamics method is proposed that improves the accuracy of the approximation especially at points near the boundary of the domain. The modified method is used to study one-dimensional wave propagation and twodimensional transient heat conduction problems.

Adenosine is increasingly used to assess for dormant conduction following pulmonary vein isolation during atrial fibrillation ablation. While the half-life of adenosine is typically short and side effects transient, operators should be aware of more serious, lasting adverse reactions including anaphylaxis and bronchospasm.

The identification of the space-dependent perfusion coefficient in the onedimensional transient bio-heat conduction equation is investigated. In this inverse coefficient identification problem, the additional measurement necessary to render a unique solution is a boundary temperature measurement. A numerical approach based on a Crank-Nicolson finitedifference scheme combined with Tikhonov’s reg...