Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a sign...

The maxillofacial region is rarely subjected to self-inflicted conditions such as factitious disease. Nasal ulceration, facial emphysema, periorbital ecchymosis, mandibular subluxation, gingival and mucosal ulceration, dental and salivary gland pain and glossopharyngeal neuralgia have been reported as possible manifestations of factitious disease. We report a case of a young woman who presented...

The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosal defense and to clarify the receptors and mechanisms that may be involved in it. Gastric ulceration was induced by oral administration of acidified ethanol in male Wistar rats. Mucosal levels of calcitonin gene-related peptide (CGRP) and somatostatin were determined by radioimmunoassay. For anal...

The relationship between acute intracerebral lesions and oesophago-gastro-duodenal ulceration has long been recognised, first by Rokitansky (1849), later by Pomorski (1891) and L#{233}pine(1895), and in more recent years by Opper and Zimmerman (1938), Strassmann (1947), Globus and Ralston (1951), Schlumberger (1951) and Dalgaard (1960). Strassmann found fifty-six instances of peptic ulceration ...

In recent years methotrexate has been used increasingly in combination chemo-therapeutic regimens for the treatment of aggressive non-Hodgkin's lymphoma. I Its principal toxic effects are bone marrow suppression, gastrointestinal mucositis, hepatitis, renal impairment, and erythematous rashes. The Stevens-Johnson syndrome has been reported previously in two children receiving high-dose methotre...

The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosal defense and to clarify the receptors and mechanisms, that may be involved in it. Gastric ulceration was induced by oral administration of acidified ethanol in male Wistar rats. Mucosal levels of calcitonin gene-related peptide (CGRP) and somatostatin were determined by radioimmunoassay. For ana...

Biopsies from 56 patients with endoscopically normal duodenal bulbs, duodenitis, or duodenal ulceration were studied for counts of plasma cells, polymorphs, and eosinophils and extent of gastric metaplasia, villous atrophy, and mucosal oedema. A correlation matrix showed that the counts of different types of plasma cells were closely correlated with each other and that there was also a close co...

Oral ulceration is a common complaint of patients attending out-patient clinics. Because of the diversity in causes of oral ulceration, patients presenting with oral mucosal disease can be challenging to diagnose and manage. Patients with signs or symptoms of oral ulcers are sometimes referred to gastroenterology clinics; however, in most instances the ulcers do not result from gastrointestinal...

∗ Corresponding author. E-mail address: [email protected] (S. Giestas). tumors and only 0.04% of small intestinal malignant neoplasms. GISTs may occur anywhere along gastrointestinal tract, but most commonly arise in the stomach (40--60%) and jejunum/ileum (25--30%). The clinical presentation of GISTs is highly variable depending on their size, location and presence of mucosal ulceration....

OBJECTIVE To assess the demographic, clinical, endoscopic and histological spectrum of Solitary Rectal Ulcer Syndrome (SRUS). STUDY DESIGN Cross-sectional observational study. PLACE AND DURATION OF STUDY Medical Unit-III, Civil Hospital Karachi (CHK) and Ward 7, Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2009 to June 2012. METHODOLOGY Patients with SRUS, based on cha...