The objective: to evaluate safety and efficacy of bedaquiline in the treatment patients with multiple drug resistant tuberculosis (MDR-TB). Subjects Methods. Clinical data 523 above 18 years old registered for MDR TB as per regimen 4 were retrospectively analyzed. HIV-negative selected divided into two groups by use chemotherapy regimen. Results. In containing bedaquiline, adverse reactions obs...

background: the eradication of helicobacter pylori infection, commonly prevailing in the stomach, has been important since its introduction. adequate preparations should be made in finding alternatives when faced with first-line treatment failures. currently, ideal second-line treatments are indistinct and varied among countries as result of different antibiotic resistance patterns. we aimed to...

BACKGROUND The efficacy of antiretroviral therapy (ART) has improved, and the adverse effects of antiretroviral drugs have been reduced. However, these adverse effects still significantly influence patient compliance, increasing the risk of tolerability failure. Therefore, we investigated the adverse effects and tolerability failure causing changes in the first ART regimen, and identified the r...

AIM To examine the preference for two dosing regimens of 20 mg of tadalafil, on demand or three times per week, in men affected with erectile dysfunction (ED) in Italy. METHODS Scheduled Use versus on demand Regimen Evaluation (SURE) is a multicenter, crossover and open-label study, involving 94 urology centers in Italy. Patients aged 18 years or older affected with ED for at least 3 months w...

INTRODUCTION Intra-amniotic infection (IAI) and early-onset postpartum endometritis (PPE) require prompt antibiotic treatment and are generally treated by either of two regimens. A complicated multi-agent regimen is most commonly used, despite a lack of clear evidence that it produces better outcomes than a simpler single-agent regimen. OBJECTIVE We compared treatment outcomes between a multi...

Aims/Objectives/Background Paracetamol overdose is the most common drug in UK. The standard treatment of toxicity intravenous N-acetylcysteine (NAC) which usually given as a 21-hour infusion UK hospitals. A 12-hour known ‘SNAP’ regimen has been implemented some centres and appears on TOXBASE. SNAP associated with fewer anaphylactoid reactions than treatment. was initiated two District General H...

Abstract Background Disseminated Mycobacterium marinum infections occur rarely, in immunocompromised patients. Treatment with a prolonged multi-drug regimen exposes patients to drug–drug interactions and side effects. Case report We case of disseminated M. infection 54-year-old renal transplant, HIV-infected woman. Manifestations the were cutaneous subcutaneous nodules, mediastinal lymph nodes ...

Introduction: Helicobacter pylori infections occur in about 50% of the world population and have a main role in the creation of peptic ulcer and its related cancer. We sought to evaluate the effectiveness of two treatment regimens on the eradication of helicobacter pylori and its complications among peptic ulcer patients. Materials and methods: By a clinical trial, patients with peptic ulcer ...