Human trefoil factor 3 (hTFF3) is a small-molecule peptide with potential medicinal value. Its main pharmacological function is to alleviate gastrointestinal mucosal injuries caused by various factors and promote the repair of damaged mucosa. However, how its transcription is regulated is not yet known. The aim of this study was to clone the hTFF3 gene promoter region, identify the core promote...

In chronically damaged tissue, trefoil factor family (TFF) peptides ensure epithelial protection and restitution. In chronic kidney disease (CKD), TFF1 and TFF2 are reported to be upregulated. Especially in the early phase, CKD is associated with silently ongoing renal damage and inflammation. Moreover, many patients are diagnosed late during disease progression. We therefore sought to investig...

Molecular trefoil knots are usually covalently assembled from rationally designed building blocks with multiple functional groups. In their Research Article (e202200748), Jie-Sheng Huang, Chi-Ming Che, and co-workers report on the use of monoalkynes a mononuclear AuI compound for self-assembly Au−C bonded Au15 featuring non-covalent AuI–AuI interactions. The structures, solution behavior, photo...

By obtaining surgery descriptions of knots which lie on the genus one fiber of the trefoil or figure eight knot, we show that these include hyperbolic knots with arbitrarily large volume. These knots admit lens space surgeries and form two families of Berge knots. By way of tangle descriptions we also obtain surgery descriptions for these knots on minimally twisted chain links.

A controlled study using a sand-tank system was conducted to evaluate 10 forage species (bermudagrass, ‘Salado’ and ‘SW 9720’ alfalfa, ‘Duncan’ and ‘Polo’ Paspalum, ‘big’ and ‘narrow leaf’ trefoil, kikuyugrass, Jose tall wheatgrass, and alkali sacaton). Forages were irrigated with sodium-sulfate dominated synthetic drainage waters with an electrical conductivity of either 15 or 25 dS/m. Forage ...

Using the existence of a special quadrisecant line, we show the ropelength of any nontrivial knot is at least 15.66. This improves the previously known lower bound of 12. Numerical experiments have found a trefoil with ropelength less than 16.372, so our new bounds are quite sharp.

1 Light RW, Cheng DS, Lee YC, et al. A single intrapleural injection of transforming growth factor(2) produces an excellent pleurodesis in rabbits. Am J Respir Crit Care Med 2000; 162:98–104 2 Lee YC, Lane KB, Parker RE, et al. Transforming growth factor (2) (TGF (2)) produces effective pleurodesis in sheep with no systemic complications. Thorax 2000; 55:1058–1062 3 Gary Lee YC, Teixeira LR, De...

The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant and detoxification enzymes. It protects organs from various kinds of toxic insults. On the other hand, activation of Nrf2 is also correlated with cancer progression and chemoresistance. Downregulation of Nrf2 activity has ...

This paper discusses algorithms for labeling sets of points in the plane, where labels are not restricted to some nite number of positions. We show that continuously sliding labels allows more points to be labeled both in theory and in practice. We de ne six di erent models of labeling, and analyze how much better | more points get a label | one model can be than another. We show that maximizin...