نتایج جستجو برای: trehalose 6
تعداد نتایج: 959076 فیلتر نتایج به سال:
The TPS1 gene, encoding trehalose-6-phosphate synthase (TPS), exerts an essential control on the influx of glucose into glycolysis in the yeast Saccharomyces cerevisiae. The deletion of TPS1 causes an inability to grow on glucose because of a hyperaccumulation of sugar phosphates and depletion of ATP and phosphate. We show that expression of the Escherichia coli homologue, otsA, in a yeast tps1...
It is well known that glycogen and trehalose accumulate in yeast under nutrient starvation or entering into the stationary phase of growth, and that high levels of trehalose are found in heat-shocked cells. However, effects of various types of stress on trehalose, and especially on glycogen, are poorly documented. Taking into account that almost all genes encoding the enzymes involved in the me...
Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P) synthase OtsA and T6P phosphatase OtsB that generate trehalose from ADP/UDP-glucose and glucose-6-phosphate. In order to assess the drug tar...
Abstract This review commemorates the 50th anniversary of Nobel Prize in Chemistry awarded to Luis F. Leloir ‘for his discovery sugar-nucleotides and their role biosynthesis carbohydrates’. He co-workers discovered that activated forms simple sugars, such as UDP-glucose UDP-galactose, are essential intermediates interconversion sugars. They elucidated biosynthetic pathways for sucrose starch, w...
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