Background: To report a case of paediatric precursor B-cell acute lymphoblastic leukaemia (ALL) presenting as uveitis masquerade syndrome (UMS).
 Case presentation: A 3-year-old girl with neutropenic sepsis presented poor fixation and right preferential gaze. Vision was light perception counting fingers in OD OS bilateral panuveitis, Roth spots, retinal haemorrhages, exudates. Vitreous bio...

Hypercalcaemia as the only manifestation of B-cell lymphoma is seen very rarely. Its pathophysiology is heterogenous and not well understood. We report a 73-year-old man who presented with severe hypercalcaemia before any signs of malignancy became evident. He was diagnosed with a B-cell lymphoma on bone marrow trephine biopsy. The hypercalcaemia was associated with high plasma concentrations o...

Iliac crest trephine biopsy specimens from 1 6 patients treated with recombinant a2-interferon (a-IFN) for hairy cell leukemia (HCL) were examined for reticulin and colIagen content. These data were compared with the hairy cell index (HCI). the proportion of hairy cells to the overall cellularity of the bone marrow. Specimens were studied immediately before a-IFN therapy. at 6-month intervals d...

Bone marrow is an exceptionally uncommon site of metastatic dissemination in angiosarcoma (AS) as only single case reports have been published so far. We report a case of a 72-year-old male with epithelioid angiosarcoma of the liver who subsequently developed erythroblastic anemia. The trephine bone marrow biopsy revealed total replacement of the normal hematopoiesis by diffuse infiltrate of AS...

Essential thrombocythaemia was first described over 70 years ago. This condition is dominated by thrombotic and haemorrhagic complications and, in the long-term, by risk of transformation to myelofibrosis and/or acute leukaemia. However, it is heterogeneous both clinically and biologically. Here, a review of current concepts in disease aetiology and management is offered with reference to recen...