a quantitative structure-activity relationship (qsar) study was conducted for the prediction of inhibitory activity of 1-phenyl[2h]-tetrahydro-triazine-3-one analogues as inhibitors of 5-lipoxygenase. the inhibitory activities of the 1-phenyl[2h]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (mlr) ...

A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.

A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The structures to have the required structural elements for any compounds be potential anticonvulsant. Preliminary screening anticonvulsant activity was performed maximal electroshock seizure (MES), subcutaneous pentylenetetrazole-induced (scPTZ) behavioral ...

The rate of CO(2) reduction in the S-triazine-resistant biotype of smooth pigweed (Amaranthus hybridus L.) was lower at all levels of irradiance than the rate of CO(2) reduction in the susceptible biotype. The intent of this study was to determine whether or not the lower rates of CO(2) reduction are a direct consequence of the same factors which confer triazine resistance. The quantum yield of...

Abstract The energetic compound 5,7‐diamino‐2‐nitro‐1,2,4‐triazolo[1,5‐a]‐1,3,5‐triazine (ANTT) was synthesized through the selective nitration of 2,5,7‐triamine‐1,2,4‐triazolo[1,5‐a]‐1,3,5‐triazine (TTT). This facile synthetic strategy yields a highly insensitive nitrogen bicycle with potential for further functionalization. ANTT chemically characterized by NMR, IR, and single crystal X‐Ray cr...

Equine protozoal myeloencephalitis (EPM) is a nervous system disease caused by the protozoan Sarcocystis neurona. The clinical syndrome caused by the disease can have a variety of presentations. Classically, horses present with asymmetric ataxia and weakness defined by multifocal central nervous system lesions. Successful management of this disease has been frustrated by failure of treatment su...

The title compound, C(19)H(28)N(8)O(2), was prepared by the reaction of N(2),N(2),N(4),N(4)-tetra-ethyl-6-hydrazino-1,3,5-triazine-2,4-diamine and 1-(4-nitro-phen-yl)ethanone in ethanol at room temperature. The mol-ecular conformation is stabilized by intra-molecular C-H⋯N hydrogen-bonding inter-actions. There are also inter-molecular N-H⋯O hydrogen bonds, and C-H⋯π and π-π inter-actions, which...

The reaction of the cyanoacetylhydrazine (1) with α-bromoketones (2a-c) gave the hydrazide-hydrazone derivatives 3a-c. The latter compounds underwent ready cyclization when heated in sodium ethoxide to form the 1,3,4-oxadiazine derivatives 4a-c. The reaction of 3a with hydrazines gave the 1,3,4-triazine derivatives 7a,b. Compounds 3a-c and 7a,b underwent some heterocyclizations when treated wit...

Esters of N-methylproline and N-allylproline were prepared and used as component for synthesis of chiral triazine based coupling reagents. N-Triazinylammonium tetrafluoroborate obtained from methylester of L-N-methylproline, 2-chloro-4,6-dimethozxy-1,3,5-triazine and tetrafluoroboric acid in the coupling of rac-Z- A1a-OH with glycine methylester preferred formation of D-Z-AlaGly-OMe with L/D ra...