Introduction: Tinea capitis is an infection caused by dermatophytes which have a particular affinity for keratin. Its prevalence decreased significantly in developed countries due to the improvement of sanitary conditions and socioeconomic level. However, they are still common in developing countries including Tunisia. The aim of our study was to evaluate the epidemiological, clinical and mycol...

Trichophyton rubrum is the most common agent of dermatophytosis, a disease that affects millions of individuals worldwide. Its molecular pathogenicity mechanisms are still not completely elucidated. It has been widely recognized that proteases secreted by T. rubrum are the key virulence factors during host infection. However, our knowledge about the expression of its secreted proteases in host ...

Dear Editor, Tinea barbae is a dermatophyte infection that affects primarily the bearded areas of the face.1 Sycosis is one type of clinical manifestation associated with deep folliculitis. The infection is usually caused by zoophilic fungi acquired after contact with animals.2 The presence of anthropophilic fungi, such as Trichophyton rubrum (T. rubrum), has recently been reported, and they of...

OBJECTIVES Arthroconidia have been considered as the primary cause of infection by dermatophytes. However, the in vitro antifungal testing evaluates the responses mainly of microconidia or hyphae, and dermatophytes in vivo often produce arthroconidia, a cellular structure presumably more resistant to antifungals. The aim of this study was to compare the in vitro susceptibility of microconidia a...

designate a type of pustular folliculitis affecting the lower classes (Indians), viz., coolies, etc., and is seen commonly on the thigh and legs. Unfortunately the use of this term has been extended to any form of purulent dermatitis, including scabies, because few attempts have been made to find the causative organism. Castellani employs the term " cooly itch " in a more restricted sense to an...

Enzyme systems concerned in the breakdown of carbohydrates by dennatophytes have been little studied, the principal contribution being a study of a number of enzymes of the glycolytic and hexosemonophosphate pathways and of the tricarboxylic acid cycle in cell-free extracts of Trichophyton mentagrophytes (Jensen, Altschuller & Bard, 1957). The effect of different substrates and pH values on the...

The therapeutic activity of two new benzofuran-imidazoles, IM/B/4-62 and IM/B/4-66, formulated as 1% cream, has been evaluated against Candida albicans and Trichophyton mentagrophytes by inducing experimental vaginal candidosis in female rats and dermatophytosis in female guinea pigs. Results of the treatment were compared with those obtained by the same therapeutic regimen carried out with bif...

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at...

Medicinal plants are facing threats due to loss of habitat and overexploitation of knows species. Therefore the present work shows utilization of essential oil from discarded leaves of Psidium guajava Linn. against human dermatophytic fungi Trichophyton rubrum, T. mentagrophytes, Trichophyton violaceum, Trichophyton tonsurans, Epidermophyton floccosum, Microsporum gypseum and Microsporum canis....