Corresponding Author: V. Fernández Laboratorio de Biología Celular y Molecular. Centro de Investigación Veterinaria de Tandil, Argentina Email: [email protected] Abstract: Fasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ). The indiscriminate use of t...

This review summarises the findings of a series of studies in which the histological changes, induced in the reproductive system of Fasciola hepatica following treatment of the ovine host with the anthelmintic triclabendazole (TCBZ), were examined. A detailed description of the normal macroscopic arrangement and histological features of the testes, ovary, vitelline tissue, Mehlis' gland and ute...

following an outbreak: of human fascioliasis in gilan province of iran in 1989, the benzimidazole derivative triclabendazole (tcbz) was suggested as the drug of choice after finding out that routine drugs were not effective. two studies were performed: a clinical trial (before/after type) in 1989 and a historical cohort (1989- 1995) to examine the efficacy of the drug. tcbz was administered to ...

Bovine fasciolosis is a parasitic disease of cattle caused by trematodes usually Fasciola gigantica and Fasciola hepatica in the tropics. The members of this genus are commonly known as liver flukes. The life cycle of these trematodes involves snail as an intermediate host (IH). The disease is found in vast water lodged and marshy grazing field condition anticipated to be ideal for the propagat...

INTRODUCTION In this study, clinical, laboratory, radiological, and serological examinations of fascioliasis patients were analyzed, and data with a significant impact on differential diagnosis were evaluated. METHODOLOGY Clinical, radiological, and laboratory findings and treatment responses of a total of 22 fascioliasis patients, treated between October 2009 and September 2014, were evaluat...

Sheep experimentally infected with the Egyptian strain of Fasciola were used to study the influence of infection on the activities of some drug-metabolizing enzymes and antioxidant capacity in the liver. Twentytwo sheep were randomly divided into a group of 12 animals (all subsequently infected with 150 metacercariae of Fasciola) and a group of ten (left uninfected, as normal controls). Three m...

Ovine fasciolosis causes high morbidity and mortality rates, resulting in large economic losses to the sheep industry in northern Tunisia. The authors surveyed ovine fasciolosis (Fasciola hepatica infestation) in a Barbarine sheep flock in the humid region of Tunisia (Sejnane, Governorate of Bizerte) over two consecutive years, 2004 to 2005. To assess the dynamics of fluke infestation, a total ...

The in vitro effect of artesunate (ATS) on the 3-week-old juveniles of Fasciola gigantica was compared with triclabendazole (TCZ) by incubating the parasites in M-199 medium containing the drugs at concentrations of 20, 40, and 80 μg/ml for 1, 3, 6, 12, and 24h. The anthelmintic activities of these drugs were evaluated based on the relative motility value (RM) and the alterations of the tegumen...

The phenotype of the hepatic inflammatory infiltrate and hepatic lymph nodes (HLN) was analysed in lambs primarily and challenge infected with Fasciola hepatica. Group 1 was primarily and challenge infected with two doses of 200 metacercariae (mc) each and was non-treated. Trickle infection was administered to five groups: group 2 was challenge infected and non-treated; group 3 was primarily in...