The new Lcica RM 2165 automatic, heavy-duty microtome has an advanced step motor that permits an exact specimen feed and reproducible sectioning results. Features include 70 mm vertical stroke length, unique step trim function, and programmable specimen retraction. Technical features include a handwheel rocking sectioning mode; the motorized specimen feed can be linked to change the handwheel t...

The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions. The crystal structure of TRIM21 PRYSPRY in complex with its target Ig...

We study the distributed control of heating, ventilation, and air conditioning systems in buildings. We present and compare two control design techniques. In the first part, a one-step distributed model predictive controller (DMPC) is introduced. We compute the explicit state-feedback solution and show how to implement it on existing networked buildings control platforms. In the second part, we...

The male-sterile ms2 mutant has been known for 40 years and has become extremely important in the commercial production of wheat. However, the gene responsible for this phenotype has remained unknown. Here we report the map-based cloning of the Ms2 gene. The Ms2 locus is remarkable in several ways that have implications in basic biology. Beyond having no functional annotation, barely detectable...

Regularization is essential for avoiding over-fitting to training data in network optimization, leading better generalization of the trained networks. The label noise provides a strong implicit regularization by replacing target ground truth labels examples uniform random labels. However, it can cause undesirable misleading gradients due large loss associated with incorrect We propose first-ord...