The tripartite motif (TRIM) family of proteins is an evolutionarily ancient group of proteins with homologues identified in both invertebrate and vertebrate species. Human TRIM22 is one such protein that has a dynamic evolutionary history that includes gene expansion, gene loss, and strong signatures of positive selection. To date, TRIM22 has been shown to restrict the replication of a number o...

Problems in operations research are often NP complete and optimal solution for larger problems cannot be obtained, therefore heuristic methods have to be used. The boundary between the size of the problem that can be solved optimally and those where heuristic methods should be used is not always clear. To solve this problem we propose a method based on decision trees. The method can be also use...

This work presents a genetic symbiotic algorithm to solve the one-dimensional cutting stock problem with multiple objectives. We considered two important objectives for an industry (1) cost of trim loss and (2) cost of setup. We use a symbiotic relationship, between the population of solutions and the population of cutting patterns, together with a niche strategy to obtain an approximation of t...

The TRIpartite Motif (TRIM) family of RING-domain-containing proteins participate in a variety of cellular functions. The β-transducin repeat-containing protein (β-TrCP), a component of the Skp-Cullin-F-box-containing (SCF) E3 ubiquitin ligase complex, recognizes the NF-κB inhibitor IκBα and precursor p100 for proteasomal degradation and processing, respectively. β-TrCP thus plays a critical ro...

In this paper the cutting stock problem for the corrugated board boxes industry is presented. The problem is solved by means of a two step strategy. First, patterns pre-generation model is formulated which are then used as input in a mathematical MILP model that optimizes the cutting process minimizing the paper trim-loss costs. Several parameters have been added to the system such that the pla...

We consider two integer linear programming models for the one-dimensional cutting stock problem that include various difficulties appearing in practical real problems. Our primary goals are the minimization of the trim loss or the minimization of the number of master rolls needed to satisfy the orders. In particular, we study an approach based on the classical column-generation procedure by Gil...

The SLAC A-Line is a transport system originally designed to deliver electron beams of up to 25 GeV to fixed target experiments in End Station A. To raise the beam energy capability of the A-Line to 52 GeV, the eight original bending magnets, plus four more of the same type, have been modified by reducing their gaps and adding trim windings to compensate for energy loss due to synchrotron radia...

BACKGROUND Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations. METHODS Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 me...