نتایج جستجو برای: tripterygium wilfordi

تعداد نتایج: 425  

Journal: :Cureus 2023

Celastrol is a pentacyclic tripterine sourced from Tripterygium wilfordii hook root. can exert certain biological functions such as antitumor, anti-inflammatory, and antiproliferative properties. was shown the previous literature to be capable of attenuating many fibrotic diseases. As effects various diseases atherosclerosis, cancer, ischemia affect more people with devastating repercussions, t...

2017
Rita Cascão João E. Fonseca Luis F. Moita

The identification of new bioactive compounds derived from medicinal plants with significant therapeutic properties has attracted considerable interest in recent years. Such is the case of the Tripterygium wilfordii (TW), an herb used in Chinese medicine. Clinical trials performed so far using its root extracts have shown impressive therapeutic properties but also revealed substantial gastroint...

Journal: :Indian journal of biochemistry & biophysics 2013
Haw-Young Kwon Kyoung-Sook Kim Hyun-Kyu An Hyung-In Moon Hyun-Jun Kim Young-Choon Lee

Triptolide, a diterpene derived from Tripterygium wilfordii Hook f., a Chinese medicinal herb, has been reported to inhibit cell proliferation and induce apoptosis in various human cancer cells, but its anticancer effects on human osteosarcoma cells have not yet been elucidated. In this study, we investigated whether triptolide induces apoptosis in human osteosarcoma cells and the underlying mo...

Journal: :Molecules 2017
Victor Forman Roberta Callari Christophe Folly Harald Heider Björn Hamberger

The development of medical applications exploiting the broad bioactivities of the diterpene therapeutic triptolide from Tripterygium wilfordii is limited by low extraction yields from the native plant. Furthermore, the extraordinarily high structural complexity prevents an economically attractive enantioselective total synthesis. An alternative production route of triptolide through engineered ...

2018
Yiqun Li Huiting Cao Mengzhu Liu Benyong Zhang Xinlong Zhang Donglei Shi Liwei Guo Jinao Duan Xueping Zhou Huaxu Zhu Qichun Zhang

Background Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the absorption process of triptolide might be involved in decreasing the toxicity in liver and kidney. Methods The absorption of triptolide, triptonide, wilforlide and tripter...

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