نتایج جستجو برای: trk
تعداد نتایج: 1237 فیلتر نتایج به سال:
Receptor tyrosine kinases (RTKs), in response to their growth factor ligands, phosphorylate and activate downstream signals important for physiological development and pathological transformation. Increased expression, activating mutations and rearrangement fusions of RTKs lead to cancer, inflammation, pain, neurodegenerative diseases, and other disorders. Activation or over-expression of ALK, ...
Neurotrophins and their Trk family receptor tyrosine kinases act on the development and function of the PNS. Numerous in vitro and in vivo studies have established the roles of each Trk receptor in neurite outgrowth, survival and differentiation (Bibel and Barde, 2000; Huang and Reichardt, 2001; Snider, 1994). The differential expression of Trk receptors in subsets of sensory neurons indicates ...
All members of the neurotrophin family of neuronal growth factors promote survival and neurite outgrowth of dorsal root ganglion (DRG) neurons in vitro. The trk family of protooncogenes encodes receptors that are now thought to mediate the biological effects of neurotrophins. In order to learn more about the dependence of DRG neurons on neurotrophins in vivo, we have studied mRNA expression of ...
INTRODUCTION The neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have been identified in the human intervertebral disc (IVD) and have been implicated in the mechanisms associated with nerve ingrowth and nociception in degeneration of the IVD. The aim of the current study was to investigate an association between neurotrophin expression in the IVD and the sev...
Abstract Purpose While there are numerous studies comparing open-view autorefractors to subjective refraction or other autorefractors, most between closed and autorefraction tend focus on children rather than young adults. The aim of this study was determine the concordance in non-cycloplegic refractive error two modern objective autorefractors: closed-view monocular Topcon TRK-2P binocular Gra...
The exchange of trophic factors by motor neurons and muscle fibers maintains the neuromuscular junction. Neurotrophic factors (muscle-derived trophic factors acting on motor neurons) and myotrophic factors (motor neuron-derived trophic factors acting on muscle fibers) may play a role in the generation of secondary myotubes and the maturation of neuromuscular junctions during development. It has...
However, enhancing neurotrophin binding is not the Cornell University Medical College only role for p75. A number of reports suggest that it New York, New York 10021 also modulates trk signaling. While it is clear that trk †Growth Factor and Regeneration Group signaling can occur in the absence of p75, the reDepartment of Neuroscience sponses are increased in its presence. For example, Max Delb...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید