نتایج جستجو برای: tumor burden

تعداد نتایج: 524097  

Journal: :Cancer research 2008
Pierrick G J Fournier Florence Daubiné Mark W Lundy Michael J Rogers Frank H Ebetino Philippe Clézardin

Bisphosphonates bind avidly to bone mineral and are potent inhibitors of osteoclast-mediated bone destruction. They also exhibit antitumor activity in vitro. Here, we used a mouse model of human breast cancer bone metastasis to examine the effects of risedronate and NE-10790, a phosphonocarboxylate analogue of the bisphosphonate risedronate, on osteolysis and tumor growth. Osteolysis was measur...

Journal: :Journal of Thoracic Oncology 2022

Non-small cell lung cancer (NSCLC) therapy has experienced important changes in survival benefit and durable anti-tumor responses due to immune checkpoint blockers (ICBs). However, ICBs show some major limitations including low response rate drug resistance unselected patients. Despite the development of new predictive biomarkers, such as PD-L1 expression, microsatellite instability (MSI), or t...

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