نتایج جستجو برای: tumor cell lysate
تعداد نتایج: 1918054 فیلتر نتایج به سال:
Abstract Glioblastoma (GBM) continues to retain its dismal prognosis despite numerous new therapeutic modalities target various aspects of the tumor. There is a need identify new, and even personalized, targetable GBM specific antigens. Our B-cell-based vaccine (BVax) generated by isolating immune experienced B cells, identified 4-1BBL, from murine secondary lymphoid organs or patient blood. We...
Two strategies to identify tumor cells were developed in this research via analyzing the activity of telomerase inside the cells, which is regarded as the mark enzyme of tumors. The lysate of cells was used to assay directly. In the electrochemical assay, the substrate of telomerase was incubated with the lysate, followed by PCR amplification of the elongated products. Then the oxidation peak c...
Carthamus tinctorius (CT), also named safflower, is a traditional Chinese medicine widely used to improve blood circulation. CT also has been studied for its antitumor activity in certain cancers. To investigate the effects of CT on the dendritic cell (DC)-based vaccine in cancer treatment, cytokine secretion of mouse splenic T lymphocytes and the maturation of DCs in response to CT were analyz...
We have documented previously that a multiple chaperone protein vaccine termed chaperone-rich cell lysate (CRCL) promotes tumor-specific T-cell responses leading to cancer regression in several mouse tumor models. We report here that CRCL vaccine generated from a mouse breast cancer (TUBO, HER2/neu positive) is also capable of eliciting humoral immunity. Administration of TUBO CRCL triggered an...
CD4(+)CD25(+) regulatory T lymphocytes (Tregs) critically contribute to the mechanisms of cancer-induced tolerance. These cells suppress anti-tumoral CD8(+) and CD4(+) T lymphocytes and can also restrain the function of APCs. We have previously documented the immunostimulatory effects of a chaperone-rich cell lysate (CRCL) anti-cancer vaccine. Tumor-derived CRCL induces tumor immunity in vivo, ...
Background The antibodies that block immunological checkpoints have been successfully applied for the treatment of cancer. Similar effects are expected by molecular targeted therapy, which primarily aims to inhibit molecular pathways for tumor cell growth and survival. Such small molecular drugs may modulate the immune system, which raises the possibility that targeted therapy might be effectiv...
PURPOSE Patients with metastatic or relapsed pediatric sarcomas receive cytotoxic regimens that induce high remission rates associated with profound lymphocyte depletion, but ultimately few survive long term. We administered adjuvant immunotherapy to patients with metastatic and recurrent pediatric sarcomas in an effort to improve outcomes. EXPERIMENTAL DESIGN Mononuclear cells were collected...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید