Tumor cells, like most other release exosomes called tumor-derived (TEX) and are vital for intercellular communication. TEX membrane-bound extracellular vesicles (EVs), containing unique cargo reminiscent of the parent tumor cells possess immunomodulatory functions. carries factors that directly promote immunosuppression in microenvironment indirectly attract immunosuppressive T-regulatory (Tre...

Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost.

Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes. This article describes several key oncogene and tumor suppressor signaling networks that have been implicated in breast cancer progression. Among the tumor suppressors, the article emphasizes BRCA1/2 and p53 tumor suppressors. In a...

Bromodomain-containing protein 4 (BRD4) is an intracellular that regulates expression of various cellular functions. This study investigated whether BRD4 inhibition can alter the immunomodulatory and antitumor effects radiation therapy (RT). A murine breast cancer cell line was implanted into BALB/c mice. The dual-tumor model used to evaluate abscopal RT. total 24 Gy delivered inhibitor injecte...