Pseudomonas aeruginosa is an important cause of infection, especially in immunocompromised patients. In this regard, strains producing carbapenemases, mainly metallo-β-lactamases (MBLs), have become a significant public health concern. Here, we present the complete annotated genome sequence (65.7 kb) of an F8-related lytic myovirus (Pbunalikevirus genus) that infects MBL-producing P. aeruginosa...

Klebsiella pneumoniae carbapenemases (KPCs) confer resistance to nearly all β-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-produc...

Introduction: Over the past few decades, antimicrobial resistance (AMR) has skyrocketed globally among bacteria within Family Enterobacteriaceae (i.e. Enterobacter spp, Klebsiella Escherichia coli, Proteus Serratia marcescens, Citrobacter and others). are intestinal flora important pathogens in nosocomial community settings. spread easily between humans may acquire AMR via plasmids or other mob...

Background: In African countries, where the burden of neonatal sepsis is highest, spread Carbapenemases Producing Enterobacteriaceae (CPE) in community, potentially contributing to mortality, a public health concern. The transmission routes are not well defined, particularly possible key role played by pregnant women. aim this study was understand acquisition CPE Yaounde, Cameroon. Methods: A t...

BACKGROUND Acinetobacter baumannii is a significant hospital pathogen, possessing a considerable degree of antimicrobial resistance. A. baumannii resistance to carbapenems and aminoglycosides is mostly conferred by class D OXA carbapenemases and aminoglycoside-modifying enzymes, respectively. The aim of this study was to determine the prevalence of selected genes encoding OXA carbapenemases and...

BACKGROUND NXL104 potentiates ceftazidime and ceftaroline against Enterobacteriaceae with extended-spectrum, AmpC, KPC and OXA β-lactamases. We examined whether similar potentiation was obtained against non-fermenters, which are less permeable than Enterobacteriaceae and have more potent efflux. METHODS MICs of ceftazidime+NXL104 (with NXL104 at 4 mg/L) and comparators were determined by CLSI...

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) co-carrying multiple carbapenemases is complicating clinical treatment. This study aimed to investigate the global dissemination trends CRKP strains that co-carry carbapenemases. isolate KP424 blaNDM-1 and blaKPC-2, recovered from a stool specimen, was identified by NG-Test Carba 5 test, genome sequence further determined using ...

To evaluate the water compartment antibiotic-resistance contamination rates, 11 wells, five streams, and four treatment plants located in the Oltrepò Pavese area were screened for the presence of third generation cephalosporins resistant Gram-negative bacteria. Enterobacteriaceae were also characterized for the Extended-Spectrum-β-Lactamases (ESBLs), carbapenemases, and mcr-1 genes presence. Fr...

The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers. In this study, we evaluated a new phenotypic test, the OXA-48 disk test, which is based on an imipenem disk and two blank disks adjacent to the imipenem disk, loa...