نتایج جستجو برای: tyrosinase inhibitors
تعداد نتایج: 192087 فیلتر نتایج به سال:
BACKGROUND Tyrosinase is an oxidoreductase that is very important in medicine and cosmetics because the excessive production of melanin causes hyperpigmentation. The development of novel, effective tyrosinase inhibitors has long been pursued. In preliminary tests, we found that an extract of the wood of Artocarpus heterophyllous (AH) potently inhibited tyrosinase activity. RESULTS Two new fla...
In this report, we show the results of quantitative structure-activity relationship (QSAR) studies of tyrosinase inhibitory activity, by using the bond-based quadratic indices as molecular descriptors (MDs) and linear discriminant analysis (LDA), to generate discriminant functions to predict the anti-tyrosinase activity. The best two models [Eqs (6) and (12)] out of the total 12 QSAR models dev...
To assess the effect of androgens on tyrosinase activity in B16/C3 melanoma cell cultures, proliferating cultures were treated with testosterone (50 nM) or one of several other androgenic analogues and metabolites. None of these compounds influenced basal enzyme activity. Imidazole (10 mM), however, is a potent inducer of tyrosinase in this cell line. Testosterone blocked induction of tyrosinas...
freckles and pigmented acne scars, are of serious concern to women. Their treatment usually involves the use of medicines or medicinal cosmetics containing depigmenting agents or skin-whitening agents. For example, hydroquinone and 4methoxyphenol are used as topical therapies for hyperpigmentation disorders. Active ingredients available for medicated whitening cosmetics in Japan include vitamin...
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