Cocaine dependence is a significant public health problem for which there are currently no FDA-approved medications. Hence, identifying candidate compounds and employing an efficient evaluation process is crucial. This paper describes key design decisions made for a National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) study that uses a novel two-stage process to evaluate buspir...

As tools for personal storage, file synchronization and data sharing, cloud storage services such as Dropbox have quickly gained popularity. These services provide users with ubiquitous, reliable data storage that can be automatically synced across multiple devices, and also shared among a group of users. To minimize the network overhead, cloud storage services employ binary diff, data compress...

AIMS Urodynamic studies (UDS) are complex, invasive and may be emotionally and physically distressing. Inadequate information may heighten distress. Prior to UDS, our patients receive written and verbal information, yet concerns remains that some women may not be adequately informed. This study examined how informed women believe they are to undergo UDS in our clinic. METHODS This was a befor...

INTRODUCTION The Uniform Data Set (UDS) contains neuropsychological test scores and demographic information for participants at Alzheimer's disease centers across the United States funded by the National Institute on Aging. Mean regression analysis of neuropsychological tests has been proposed to detect cognitive decline, but the approach requires stringent assumptions. METHODS We propose usi...

The conformational order of three alkanesulfonates, sodium hexanesulfonate (HS), sodium undecanesulfonate (UDS), and sodium dodecanesulfonate (DDS), adsorbed at the D2O/CCl4 interface are examined in detail by sum-frequency vibrational spectroscopy. An increase in surfactant concentration at the interface results in the reduction of gauche defects in the hydrocarbon chains as determined from th...

ABSTRACT Galaxies with little star formation are found to have quenched over a variety of time-scales, which provides insights into the physical mechanisms responsible. Here, we examine population rapidly galaxies (RQGs) in Simba cosmological hydrodynamic simulation at 0.5 < z 2, and compare them directly observed post-starburst UKIDSS Ultra Deep Survey (UDS) via their colour distributio...

This paper proposes a probabilistic load flow (PLF) methodology using uniform design sampling (UDS). The correlation between input random variables has been taken into consideration. The random numbers of random variables uniformly distributed in (0,1) are generated by UDS, and subsequently converted into random numbers of input random variables with desired marginal distributions by marginal t...

Received: Revised: Accepted: March 16, 2013 June 28, 2013 July 7, 2013 A 2-year-old, intact male Siberian Husky was presented with corneal opacity, eye lid swelling, depigmentation, alopecia and erythema predominantly on face. Bilateral uveitis preceded periocular and nasal planum depigmentation. Ancillary tests excluded other systemic diseases. Histopathology of the skin revealed lichenoid int...

Since the introduction of Dale's principle of "one neuron releases one transmitter at all its synapses," a growing number of exceptions to this principle have been identified. While the concept of neurotransmitter co-release by a single neuron is now well accepted, the specific synaptic circuitry and functional advantage of co-neurotransmission remain poorly understood in general. Here we repor...

This paper proposes a decentralized control scheme that mitigates floods in urban drainage systems (UDSs). First, we develop partitioning algorithm of the UDS relying on graph model system. Once this is done, design local controller for each partition based replicator dynamics (a set differential equations describes evolution population players involved strategic game). The nature proposed stra...