BACKGROUND Genetic factors are the main cause of early miscarriage. This study aimed to investigate aneuploidy in spontaneous abortion by fluorescence in situ hybridization (FISH) using probes for 13, 16, 18, 21, 22, X and Y chromosomes. METHODS A total of 840 chorionic samples from spontaneous abortion were collected and examined by FISH. We analyzed the incidence and type of abnormal cases ...

Antiphospholipid antibody (aPL) is a heterogeneous group of autoantibodies directed against phospholipids-binding proteins. Antiphospholipid syndrome (APS) is defined by two major components: 1) presence of at least one type of aPLs, 2) the occurrence of at least one clinical feature from a list of potential disease manifestations, the most common of which are categorized as venous or arterial ...

Recurrent abortion is classically defined as three or more consecutive pregnancy losses, although recently more than two pregnancy losses also considered as recurrent abortions. This condition affects approximately 1% of couples at reproductive age. Recurrent pregnancy loss has been attributed to anatomic uterine pathologies, genetic defects, endocrine disorders, immunologic factors, prothrombo...

UNLABELLED Human reproduction is not considered a highly efficient biological process. Before the end of the first trimester, 30%-50% of conceptions end in spontaneous abortion. Most losses occur at the time of implantation. 15%-20% of clinical pregnancies end in spontaneous abortions. Recurrent pregnancy loss is a frustrating clinical problem both for clinicians and patients. Recurrent pregnan...

INTRODUCTION Recurrent abortion (RA) may be a consequence of aberrant expression of immunological factors during pregnancy. Although the relative importance of immunological factors in human reproduction remains controversial, substantial evidence suggests that autoantibodies contribute to reproductive failure. Production of such antibodies is under the control of cytokines; and leptin, besides...

objective: unexplained recurrent spontaneous abortion (ursa) is one of the main complications of pregnancy which is usually defined as three or more consecutive pregnancy losses before the 20th week of gestation without a known cause. vascular endothelial growth factor (vegf) is a potent angiogenic factor and shown, along with its receptors (vegfr1, 2), to play important roles in several physio...

Background: The maximum probability of conceiving during a menstrual cycle is only about 40%. One third of conceptions do not result in the delivery of a baby recurrent miscarriage, defined as the loss of 3 or more pregnancies before 20 weeks post-menstruation that affects 1% of all women. Approximately 20 percent of pregnant women will have some bleeding before 20 weeks’ gestation, and roughly...

The objective of this study was to compare the concentrations of Th1 (IFN-γ , TNF-α) and Th2 (IL-4,IL-10) cytokines in the serum of normal pregnant and recurrent spontaneous abortion (RSA) women in 1st trimester as well as in the normal fertile non pregnant women. In RSA women there was a significant increasing in the mean concentration of Th1 cytokines (TNFα and IFNγ) as well as in Th1/TH2 tha...