Interferon regulatory factor (IRF) family members, especially interferon regulatory factor-1 (IRF-1) and interferon regulatory factor-8 (IRF-8 or ICSBP), play important roles in interferon signaling in a wide range of host responses to infection and tumor growth. Interleukin-27 (IL-27), as a member of the IL-12 cytokine family, not only acts as a proinflammatory cytokine that regulates the diff...

The present review focuses on recent advances in the understanding of the molecular mechnisms by which interferon regulatory factor (IRF)-1 inhibits oncogenesis. IRF-1 is associated with regulation of interferon α and β transcription. In addition, numerous clinical studies have indicated that IRF-1 gene deletion or rearrangement correlates with development of specific forms of human cancer. IRF...

IFN-gamma is a key cytokine controlling Brucella infection, and the diverse functions of this cytokine are mediated by IFN regulatory factors (IRFs) such as IRF-1, IRF-2, and IFN consensus sequence binding protein (ICSBP). However, the roles of these three IRFs in Brucella infection have not been investigated. The infection of each IRF-deficient mouse strain provides an opportunity to determine...

This paper presents a new model of anaphoric processing that utilizes the establishment of coherence relations between clauses in a discourse. We survey data that comprises a currently stalemated argument over whether VP-ellipsis is an inherently syntactic or inherently semantic phenomenon, and show that the data can be handled within a uniform discourse processing architecture. This architectu...

If we understand architecture as a three-part system formed by the building, its image, or drawings and images describing buildings, critical discourse around architecture, then texts ways of speaking about play key role in understanding field development. By analysing corpus 4.6 million words from written between 2005 2020 that form part computational (understood result intense digitalization ...

Inferring implicit discourse relations in natural language text is the most difficult subtask in discourse parsing. Surface features achieve good performance, but they are not readily applicable to other languages without semantic lexicons. Previous neural models require parses, surface features, or a small label set to work well. Here, we propose neural network models that are based on feedfor...

Our understanding of the post-translational processes involved in regulating the interferon regulatory factor-1 (IRF-1) tumor suppressor protein is limited. The introduction of mutations within the C-terminal Mf1 domain (amino acids 301-325) impacts on IRF-1-mediated gene repression and growth suppression as well as the rate of IRF-1 degradation. However, nothing is known about the proteins tha...

Instruction Register File (IRF) was originally proposed to reduce the power consumption of a microprocessor by providing the indirect access to frequently executed instructions. The IRF is also an attractive and cost-effective unit to protect embedded software from analysis, plagiarism, and falsification. For this purpose, the correspondences between IRF entries and their original instructions ...

Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus hemagglutinin (HA) and nucleoprotein vaccine DNAs. Cotransfection of HA with IRF-3 and IRF-7 increased CD4 T-cell responses by 2- to 4-fold and CD8 T-cell responses by more than 10-fold. Following intramuscular deliveries of DNA, both CD4 and CD8 T cells were biased towards type 1 ...

The transcription factor interferon regulatory factor-1 (IRF-1) is induced by many tumor-suppressive stimuli and can mediate antiproliferative and proapoptotic effects in cancer cells. Thus, identifying agents that enhance IRF-1 activity may be an effective approach to cancer therapy. A cell-based screening assay was developed to identify extracts and compounds that could enhance IRF-1 activity...