The actin cytoskeleton serves as a barrier that protects mammalian cells from environmental pathogens such as bacteria, fungi, and viruses. Several components of antimicrobial signaling pathways have been shown to associate directly with the actin cytoskeleton, indicating that the cytoskeleton may also serve as a platform for immune-associated molecules. Here we report that retinoic acid-induce...

studying the dialogue properties in rigveda and avesta indicates a type of dialogue called “philosophical dialogue” that is the synonym of “nonviolence”. according to the author, the initial root of forming the dramatic dialogue is based on philosophical dialogue, i.e. a type of fluidity and flow of meaning between two sides of the relation and by such relation it will be made a new concept. th...

A systematic analysis on the use of the lattice Boltzmann method (LBM) for predicting the permeability of packed beds is presented. A filtration rig is used to obtain permeability measurements of beds of glass beads, sand and crushed minerals. Subsequently, X-ray microtomography is employed to image bed samples for use as input to LBM calculations. Uncertainties in accuracy and reliability of p...

in desert areas high temperature and low precipitation limit growth and development of plants. under this circumstances wind becomes the most important erosion and transportation factor in these areas. there are four great sand masses in the central part of dasht-e-kavir namely rig-e-jen, rig-e-sargardan (shotori or halvan), rig-e-kharturan, and rig-e- chah-e-jam. these great sandy masses show ...

Aircraft engine noise research and development depends on the ability to study and predict the noise created by each engine component in isolation. The presence of a downstream pylon for a model fan test, however, may result in noise contamination through pylon interactions with the free stream and model exhaust airflows. Additionally, there is the problem of separating the fan and jet noise co...

Animal cells use a group of innate immune sensors to detect viral invasion. The RIG-I-like receptor (RLR) family of RNA helicases is largely responsible for detecting replicating viral RNAs in the cytosol of most, if not all, cells infected with RNA viruses (Rehwinkel & Reis e Sousa, 2010). Two RLRs, RIG-I and MDA5, recognize different types of viral RNA, and thus launch antiviral immune respon...

RIG-I is a well-studied sensor of viral RNA that plays a key role in innate immunity. p97 regulates a variety of cellular events such as protein quality control, membrane reassembly, DNA repair, and the cell cycle. Here, we report a new role for p97 with Npl4-Ufd1 as its cofactor in reducing antiviral innate immune responses by facilitating proteasomal degradation of RIG-I. The p97 complex is a...

Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and RIG-I-mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoyl...

The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. We investigated the roles of each pattern recognition receptor in rhinovirus infection using primary bronchial epithelial cells. TLR3 was constitutively expressed; however, RIG-I and MDA5 were inducible by 8-12 h following rhinovirus infection. Bronchial epithel...

Retinoic acid-inducible gene I (RIG-I) initiates a rapid innate immune response upon detection and binding to viral ribonucleic acid (RNA). This signal activation occurs only when pathogenic RNA is identified, despite the ability of RIG-I to bind endogenous RNA while surveying the cytoplasm. Here we show that ATP binding and hydrolysis by RIG-I play a key role in the identification of viral tar...