BACKGROUND Alexithymia is thought to be associated with the development of medically unexplained physical symptoms (UPS). So far little research has been published on alexithymia as a risk factor for the persistence of UPS. OBJECTIVE To determine the clinical outcome in UPS patients and to study the relative importance of alexithymia in predicting that outcome. METHODS A follow-up study was...

Postoperative epidural analgesia often needs rate readjustment using top-ups. Patient-controlled epidural analgesia (PCEA) is said to reduce the requirement of epidural top-ups when compared to continuous epidural analgesia (CEA). We compared CEA and PCEA in major thoracic and abdominal surgery, in a cohort study. The primary endpoint was the required number of epidural top-ups. Secondary endpo...

New technology based start-ups play a very important role in developing the economy of a country. In India, telecom sector has seen unprecedented growth over the last decade and this has led to emergence of several telecom related start-ups. However, product based B2B start-ups are rare and existing ones have to undergo several challenges in commercializing. Surprisingly not much research work ...

The topic of distinguishing atypical fibroxanthoma (AFX) from undifferentiated pleomorphic sarcoma (UPS), formerly malignant fibrous histiocytoma, is highly controversial. Although their clinical behavior is disparate, AFX and UPS commonly appear nearly identical on routine histopathologic examination. Although conceptually useful, subcategorization of UPS into superficial (confined to the derm...

Impairment of the ubiquitin-proteasome system (UPS) has long been considered an attractive hypothesis to explain the selective dysfunction and death of neurons in polyglutamine disorders such as Huntington's disease (HD). The fact that inclusion bodies in HD mouse models and patient brains are rich in ubiquitin and proteasome components suggests that the UPS may be hindered directly or indirect...

In eukaryotes, regulated protein turnover is required during many cellular processes, including defense against pathogens. Ubiquitination and degradation of ubiquitinated proteins via the ubiquitin-proteasome system (UPS) is the main pathway for the turnover of intracellular proteins in eukaryotes. The extensive utilization of the UPS in host cells makes it an ideal pivot for the manipulation o...

The presence of endoplasmic reticulum (ER) stress and impaired ubiquitin-proteasome system (UPS) activity has been independently implicated in the pathophysiology of conformational diseases. Here, we reveal a link between ER stress and the functionality of the UPS. Treatment of cells with different ER stressors delayed the degradation of an ER reporter substrate and caused a subtle but consiste...

اخیراً داده‌ها در سازمان‌ها به دارایی ارزشمندی تبدیل شده‌اند و حاکمیت داده یکی از اولویت‌های شده است. بررسی مطالعات پیشین نشان می‌دهد که سنجش استقرار به‌صورت کیفی انجام می‌شود نمی‌توانند بر اساس این نوع برنامه‌ای را برای بهبود وضعیت خود تعیین کنند. هدف پژوهش، ارائه روشی کمّی سطح یک سازمان متعاقباً برنامه‌ریزی موجود با توجه ماهیت عوامل تأثیرگذار میزان مفاهیم فازی مدل‌سازی تحلیل استفاده است؛ همچنین ...