نتایج جستجو برای: urocortin

تعداد نتایج: 684  

Journal: :Endocrinology 2014
Tsukasa Nozu Kaoru Takakusaki Toshikatsu Okumura

Several recent studies suggest that peripheral corticotropin-releasing factor (CRF) receptor type 1 (CRF1) and CRF2 have a counter regulatory action on gastrointestinal functions. We hypothesized that the activity balance of each CRF subtype signaling may determine the changes in colonic motility and visceral sensation. Colonic contractions were assessed by the perfused manometry, and contracti...

Journal: :The Journal of Clinical Endocrinology & Metabolism 2005

Journal: :The Journal of Clinical Endocrinology & Metabolism 2003

2010
Seán P Barry Kevin M Lawrence James McCormick Surinder M Soond Mike Hubank Simon Eaton Ahila Sivarajah Tiziano M Scarabelli Richard A Knight Christoph Thiemermann David S Latchman Paul A Townsend Anastasis Stephanou

The urocortin (UCN) hormones UCN1 and UCN2 have been shown previously to confer significant protection against myocardial ischaemia/reperfusion (I/R) injury; however, the molecular mechanisms underlying their action are poorly understood. To further define the transcriptional effect of UCNs that underpins their cardioprotective activity, a microarray analysis was carried out using an in vivo ra...

Journal: :Brain research 2002
Brant A De Fanti J Alfredo Martínez

The corticotropin-releasing hormone (CRH) system, including CRH and urocortin (UCN), is implicated in the central control of appetite and energy metabolism. Urocortin, a recently isolated neuropeptide closely related to CRH is involved in the central signaling cascade that inhibits energy intake. When administered intracerebroventricularly and intra-hypothalamically, UCN potently decreases food...

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