The identification of genes in the human genome remains a challenge, as the actual predictions appear to disagree tremendously and vary dramatically on the basis of the specific gene-finding methodology used. Because the pattern of conservation in coding regions is expected to be different from intronic or intergenic regions, a comparative computational analysis can lead, in principle, to an im...

One of the most applied methods in drug industry for development of new drugs is 3D-QSAR methodology. As p38-mitogen-activated protein kinase (p38-MAPK) plays a crucial role in regulating the production of such proinflammatory cytokines as tumor necrosis factor-α (TNF-α) and interleukin-1, emerging as an attractive target for new anti-inflammatory agents, we used a 3D-QSAR based method of Compa...

This article critiques the Fuzzy-set Qualitative Analysis (fs/QCA) methodology by examining its applicability in three studies in the field of comparative social policy. In each of these three test cases, I focus on the validity of fuzzy-set’s claimed function – its ability to combine theoretic discourse and evidence analysis. All three studies investigate welfare state reform in the late twent...

We develop and illustrate a methodology for obtaining robust comparative statics results for collusion models in markets with differentiated goods by analyzing the homogeneous goods limit of these models. This analysis reveals that the impact of parameter changes on the incentives to deviate from collusion and the punishment profits are often of different order of magnitude yielding comparative...

the narrow operating window between pore pressure and fracture pressure makes drilling difficult in some operations. a feasibility study of managed pressure drilling (mpd) is carried out on iran darquain oil field. the previous wells drilled in this field showed that mud returns were lost during drilling gadvan formation. the present work addresses this problem by means of surface back pressure...

The KL-ONE concept langu age provides role-value ma.ps (RVMs) as a concept forming operator that compares sets of role fillers. This is a useful means to specify structural properties of concepts. Recently, it has been shown that concept languages providing RVMs together with some other common concept-forming operators induce an undecidable subsumption problem. Thus, RVMs have been restricted t...