A liquid chromatographic method coupled with UVVis and photodiode–array detection for the determination of nitrofuran residues: nitrofurazone, nitrofurantoin, furazolidone, and furaltadone in water was developed and validated. Confirmation of the identity of nitrofurans was performed by liquid chromatography–mass spectrometry with atmospheric pressure chemical ionization interface. The nitrofur...

Spectrophotometric method is often recommended in dissolution testing of not only tablets or capsules but also suppositories. Dissolution rate of diclofenac sodium was studied using a pharmacopoeial flow-through apparatus and pH 7.3 buffer. For two lipophilic suppository bases (Witepsol W-32 and H-19) dissolution rate was overestimated with the spectrophotometric zero-order method in comparison...