Background We have observed persistent desensitization to exogenous norepinephrine after balloon injury. We postulated that this desensitization may be due to a local increase in the release of neuronal norepinephrine. Methods and Results New Zealand White rabbits underwent left iliac artery angioplasty; 4 weeks later, both iliac arteries were harvested. Maximal response to exogenous norepineph...

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis is characterized by amyopathic DM with interstitial lung disease (ILD). Here, we investigated whether autoimmunity against MDA5 has a pathological role in the development of ILD. C57BL/6 mice were immunized emulsion including recombinant mouse whole protein once week for 4 times. The MDA5-immunized intranas...

Introduction: Several lunar highland meteorites were found in the Dhofar region of Oman. Here we report the first data on the petrography and mineralogy of four new lunar stones, Dhofar 304, 305, 306 and 307. Dh-304 was found close to Dh-025 and 301, whereas Dh-305, 306 and 307 were recovered nearby Dh-081, 280, 302 and 303. The new meteorites are moderately weathered, impact-melt breccias. No ...

The safety and clinical utility of repeated administrations of 111In-ZCE 025 were evaluated in 25 patients who have undergone colorectal carcinoma resection. Fifteen patients were clinically and radiologically free of recurrences and asymptomatic while 10 had rising CEA and/or symptoms. We repeatedly imaged the patients following intravenous administrations of 40 mg ZCE 025, every 4 to 6 mo. Si...

OBJECTIVE To analyse the outcomes of laparoscopic versus open repair for perforated peptic ulcers (PPU). METHODS All patients undergoing PPU repair between January 2002 and March 2012 were included in the study. Demographic characteristics, operation time, complications, and length of hospital stay were evaluated. RESULTS Two hundred and twelve patients (median age, 49 years) were included,...

Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-forgestational-age (AG...