We investigate the potential of using electronic health record (EHR) data for improving healthcare for mental illness. Our focus is depression, a prevalent disorder that is difficult to diagnose and treat. We developed and evaluated models that use EHR data for predicting the diagnosis of depression and levels of severity, as well as identifying moderators for personalized treatment. The models...

Indicator cotton swabs have been developed in order to enable faster, less expensive, and simpler information gathering of a wound status. Swabs are normally used for cleaning the wound, but here, they were covalently functionalized with indicator chemistry. Thus, they in principle enable simultaneous wound cleaning and wound pH detection. Using an indicator dye with a color change from yellow ...

The reaction catalyzed by carbamoyl phosphate synthetase (CPS) from Escherichia coli was examined for the formation of several transient intermediates. The chemical mechanism for CPS has been previously postulated to involve the formation of carboxy phosphate and carbamate as transient intermediates. However, it is uncertain whether the carbamate arises from the reaction of ammonia with the car...

Microinjection molding is based on the concept of vario-thermal processing in which the injection unit heats the polymer and presses it into a micro featured mold. After the unit cools, the featured part is de-molded. An inherent problem with microinjection molding is poor feature replication. The polymer in the micro-cavity instantaneously freezes when it comes in contact with the mold wall th...

AbstrAct Several studies have examined how fecal indicator bacteria (FIB) measurements compare between quantitative polymerase chain reaction (QPCR) and the culture methods it is intended to replace. Here we extend those studies by examining the stability of that relationship within a beach, as affected by time of day and seasonal variations in source. Enterococcus spp. were quantified at three...

Aim: To examine the association between a healthy diet, assessed by the Healthy Diet Indicator (HDI), and cognitive decline in older adults. Methods: Data from 21,837 participants aged ≥ 55 years from 3 cohorts (Survey in Europe on Nutrition and the Elderly, a Concerted Action Accepted: February 18, 2017 Published online: March 22, 2017 Agnes A.M. Berendsen Division of Human Nutrition Wageninge...

In the social sciences, a considerable amount of research seeks to make comparisons between groups of people. These groups may be defined by nationality, culture, gender, race, or the same people at different points in time. Regardless of the substantive research questions, a key assumption is that the observed variables on which these comparisons are based, typically sets of items or scales, a...

The accurate detection of lymph node metastases is one of the most important challenges in cancer imaging today, for the presence of nodal disease is a powerful adverse prognostic indicator. Pre-treatment detection of malignant nodes determines patient management, frequently distinguishing surgical candidates from those best suited to non-surgical therapy. However, the results of CT and MR imag...

Human and rodent solid tumors often exhibit elevated interstitial fluid pressure (IFP). This condition is recognized as a prognostic indicator for reduced responses to therapy and decreased disease-free survival rate. In the present study, we tested whether induction of a thermoregulatory-mediated increase in tissue blood flow, induced by exposure of mice to mild environmental heat stress, coul...

The motion of dislocations in irradiated materials has unique features that are not seen in unirradiated materials undergoing plastic deformation. In the present work, we show dislocation dynamics studies that reveal the single and collective aspects of dislocation motion in materials under displacement cascade damage. First, we investigate the dynamics of dislocation interaction with irradiati...