alveolar ridge is underdeveloped in ectodermal dysplasia (ed). the available treatment plans include fixed, removable or implant-supported prostheses, alone or in combination. a 5 year-old boy was referred for treatment to the department of prosthodontics, tehran university of medical sciences with the chief complaint of missing teeth. prosthodontic treatment was performed to improve masticatio...

background and objective: vascular endothelial growth factor (vegf) and its receptors (vegf-r1 and r2) are major regulators of angiogenesis. this study was designed to assess serum levels of vegf and vegf-r1 and their prognostic significance in newly diagnosed childhood acute leukemia. materials and methods: for this purpose, vegf and vegf-r1 were determined using enzyme linked immuno-sorbant a...

Introduction and objectives: The diagnosis of malignant and potentially malignant epithelial lesions of the oral mucosa cannot be based solely on clinical findings. Therefore, histologic evaluation of a representative biopsy specimen is necessary. However, the site for the biopsy is always a subjective choice that sometimes raises doubts about its representativeness. Colposcopy, a well-known gy...

Loss-of-function activin receptor-like kinase 1 gene mutation (ALK1+/-) is associated with brain arteriovenous malformations (AVM) in hereditary hemorrhagic telangiectasia type 2. Other determinants of the lesional phenotype are unknown. In the present study, we investigated the influence of high vascular flow rates on ALK1+/- mice by manipulating cerebral blood flow (CBF) using vasodilators. A...

Introduction: Dentin dysplasia is a rare autosomal dominant inheriting disturbance of dentin formation characterized by normal enamel formation, but atypical dentin with abnormal pulpal morphology. There are two major patterns: type I and type II. Amelogenesis imperfecta is an autosomal dominant. X-link inherent disease that is classified by clinical manifestation into hypoplastic, hyp...

HYPOTHESIS Cyclooxygenase 2 (COX-2), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor (EGFR) are useful biological determinants in targeted therapy for esophageal adenocarcinoma. DESIGN Prospective analysis. SETTING University tertiary referral center. PATIENTS Sixteen patients with squamous mucosa and normal results of a pH study without mucosal injury (con...

dentin dysplasia is an exceptionally rare, autosomal-dominant, hereditary condition, primarily characterized by defective dentin formation affecting both the deciduous and permanent dentitions. the etiology remains imprecise to date, in spite of the numerous hypotheses put forward and the constant updates on this condition. this case report of type i dentin dysplasia exhibits radiographic fi nd...

Chorioamnionitis is associated with preterm delivery and bronchopulmonary dysplasia (BPD), characterized by impaired alveolar and pulmonary vascular development and vascular dysfunction. To study the vascular effects in a model of chorioamnionitis, preterm lambs were exposed to 20 mg of intra-amniotic endotoxin or saline for 1, 2, 4, or 7 days and delivered at 122 days gestational age (term = 1...

developmental dysplasia of the hip (ddh) or congenital hip dysplasia (cdh) is the most prevalent developmental childhood hip disorder. it includes a wide spectrum of hip abnormalities ranging from dysplasia to subluxation and complete dislocation of the hip joint. the natural history of neglected ddh in adults is highly variable. the mean age of onset of symptoms is 34.5 years for dysplastic dd...