In Part I and Part II of these two companion papers (henceforth called Part I and Part II), we develop and evaluate a variational Bayesian expectation maximization (VBEM) method for model inversion of our multi-area extended neural mass model (MEN). In this paper, we develop the VBEM method to estimate posterior distributions of parameters of MEN. We choose suitable prior distributions for the ...

PURPOSE VB-111 is an antiangiogenic agent consisting of a nonreplicating adenovirus vector (Ad-5) with a modified murine pre-proendothelin promoter leading to apoptosis of tumor vasculature by expressing a Fas-chimera transgene in angiogenic endothelial cells. In a phase I dose-escalation study, pharmacokinetics, pharmacodynamics, safety, and efficacy of a single dose of VB-111 in patients with...

Scytonema tolypothrichoides VB-61278, a terrestrial cyanobacterium, can be exploited to produce commercially important products. Here, we report for the first time a 10-Mb draft genome assembly of S. tolypothrichoides VB-61278, with 214 scaffolds and 7,148 putative protein-coding genes.

Freestanding gold nanowires (AuNW) were incorporated to fabricate a miniaturized gas ionization sensor. The device exhibited improved ensitivity in sub-Torr pressure (P) regime compared to similar devices reported earlier, since the room temperature breakdown voltage (Vb) as further reduced in low gas pressures or concentrations (N). Also excellent selectivity was achieved for pressures up to 1...

In thoracic-spinal-cord-transected rats, mean circulatory pressure (Pmc) was measured during brief circulatory arrest by inflating an indwelling balloon in the right atrium and total blood volume (VB) was measured with 51Cr. The Pmc-VB relationship was determined over the range +/- 30% VB by rapid blood infusion or withdrawal. An infusion of 1.5 microgram/kg per min of epinephrine for 20-40 min...

Electron attachment to uracil was investigated by applying time-resolved photoelectron imaging to iodide-uracil (I(-)U) complexes. In these studies, an ultraviolet pump pulse initiated charge transfer from the iodide to the uracil, and the resulting dynamics of the uracil temporary negative ion were probed. Five different excitation energies were used, 4.00 eV, 4.07 eV, 4.14 eV, 4.21 eV, and 4....

Robust GABA-mediated inhibitory postsynaptic currents (IPSCs) in neurons of the thalamic relay (TC) nuclei are important in sustaining oscillatory activity within thalamic and thalamocortical circuits. The biophysical properties and pharmacological sensitivities of these IPSCs both depend on the subunit combination of postsynaptic gamma-aminobutyric acid-A (GABA(A)) receptors. Recombinant GABA(...

STUDY OBJECTIVES We evaluated the feasibility, safety, and efficacy of CT-guided transbronchial biopsy (TBB) using an ultrathin bronchoscope with navigation by virtual bronchoscopy (VB) for small peripheral pulmonary lesions of < 20 mm in diameter. DESIGN A pilot study. SETTING A national university hospital. PATIENTS We performed CT-guided TBB after VB navigation for 25 patients with 26 ...