نتایج جستجو برای: vertical coplanar vcp
تعداد نتایج: 99181 فیلتر نتایج به سال:
We described an autopsied case of amyotrophic lateral sclerosis (ALS)dementia with p.R487H mutation in the VCP gene. TDP-43-positive neuronal cytoplasmic inclusions (NCI), neuronal intranuclear inclusions (NII) and glial cytoplasmic inclusions were observed in the brain. The frequency of NCI was small but equal to that of NII, an atypical finding for VCP-related disorders. In contrast, the find...
An important and widely neglected aspect of the interaction between an accretion disc and a massive companion with a coplanar orbit is the vertical component of the tidal force. As shown by Lubow, the response of the disc to vertical forcing is resonant at certain radii, at which a localized torque is exerted, and from which a compressive wave (p mode) may be emitted. Although these vertical re...
Elevated valosin containing protein (VCP/p97) levels promote the progression of non-small cell lung carcinoma (NSCLC). Although many VCP inhibitors are available, most of these therapeutic compounds have low specificity for targeted tumor cell delivery. Hence, the primary aim of this study was to evaluate the in vitro efficacy of dendrimer-encapsulated potent VCP-inhibitor drug in controlling n...
INTRODUCTION Vernix caseosa peritonitis (VCP) is a rare and poorly recognised condition resulting from a sustained foreign body reaction to the vernix caseosa of the baby. This case-based review aims to highlight its importance for any medical team managing patients with peritonitis who have undergone a recent Caesarean section. CASE REPORT A 31-year-old woman presented 5 weeks after a Caesa...
After showing that lower bound is not the only important parameter to balance subproblems between queues of best-rst B&B distributed algorithms, we introduced another notion of priority between subproblems that takes into account not only their lower bound but also their capacity to generate other subproblems. We developed three load balancing strategies using this new notion of priority, with ...
Human Fas-associated factor 1 (hFAF1) is a novel protein having multiubiquitin-related domains. We investigated the cellular functions of hFAF1 and found that valosin-containing protein (VCP), the multiubiquitin chain-targeting factor in the degradation of the ubiquitin-proteasome pathway, is a binding partner of hFAF1. hFAF1 is associated with the ubiquitinated proteins via the newly identifie...
Imbalanced protein homeostasis, such as excessive protein synthesis and protein aggregation, is a pathogenic hallmark of a range of neurological disorders. Here, using expression of mutant proteins, a knockdown approach and disease mutation knockin mice, we show that VCP (valosin-containing protein), together with its cofactor P47 and the endoplasmic reticulum (ER) morphology regulator ATL1 (At...
215th ENMC International Workshop VCP-related multi-system proteinopathy (IBMPFD) 13–15 November 2015, Heemskerk, The Netherlands Teresinha Evangelista , Conrad C. Weihl , Virginia Kimonis , Hanns Lochmüller * on behalf of the VCP related diseases Consortium # a John Walton Muscular Dystrophy Research Centre and MRC Centre for Neuromuscular Diseases, Institute of Genetic Medicine, Newcastle Uni...
Vesnarinone is a synthetic quinolinone derivative used in the treatment of cardiac failure and cancer. It is also known to cause agranulocytosis as a side effect, which restricts its use, although the mechanism underlying agranulocytosis is not well understood. Here, we show that vesnarinone binds to valosin-containing protein (VCP), which interacts with polyubiquitinated proteins and is essent...
Many care robots have received a lot of attention to help elderly people, however existing care robots have difficult to adapt personalization. For instance, some programmers have to customize robot program to meet needs of individual. In this paper, the authors’ goal is design and develop care robot which provides personalization for an individual elderly people with an efficient and reasonabl...
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