Amyloid fibrils from two cases of cancer-associated, systemic amyloidosis with renal cell carcinoma and mesothelioma as the respective underlying disorders were studied. The immunochemical studies suggested strongly that amyloid A comprised a principal fibril component in both cases of cancer-associated amyloidosis. This was definitively proven by amino acid sequence analyses, which revealed st...

The clinical management of amyloidosis is based on the treatment of the underlying etiology, and accurate identification of the protein causing the amyloidosis is of paramount importance. Current methods used for typing of amyloidosis such as immunohistochemistry have low specificity and sensitivity. In this study, we report the development of a highly specific and sensitive novel test for the ...

Since the first reports of amyloid being “cellulose” (reported by Virchow in the mid-1850s) and the identification of amyloid fibril ultrastructure in the late 1950s, amyloidosis has remained an enigmatic disease. However, progress in our ability to diagnose and treat amyloidosis has advanced tremendously in recent years. The use of chemotherapy and immunomodulatory agents has changed AL amyloi...

El síndrome cistocerebral fue descrito por primera vez en 1990 Blackburn y Dunn. Los casos estudiados fueron varones ancianos con confusional agudo retención urinaria aguda que, tras un drenaje vesical, presentaron resolución completa del cuadro clínico. Se reporta el caso de anciano disminución rápida nivel consciencia, mioclonías, hipotensión arterial, bradicardia orina que experimentó total ...

The musculature of the ureter has a layered arrangement in which the internal layer is mainly longitudinal and the external layer is largely circular. There is, however, intermingling and migration of fascicles between layers. At the passage of the ureter through the bladder wall this layering is lost and all fascicles become oriented longitudinally. At the ureterovesical junction fibers of the...

To the Editor of "The Indian Medical Gazette." Sir,?Lieut.-Colonel Vivian B. Bennett, in his important article 011 the treatment of vesical calculus which appeared in last November's issue of this Gazette, wrote : " In the Indian Medical Gazette of last June, Keegan has written a paper objecting strongly to the Suprapubic Operation." If Liieut.-Colonel Bennett will peruse my paper he will find ...

OBJECTIVE After endoscopic resection of high-grade superficial urothelial neoplasms (Ta, T1 or Tis), adjuvant bacillus Calmette-Guérin (BCG) therapy is performed routinely to avoid recurrence and/or progression. Vesical biopsies often are performed to assess the efficacy of treatment. The aim of our study was to evaluate the usefulness of these biopsies. MATERIALS AND METHODS During this retr...

BACKGROUND Clinical temperature management remains challenging. Choosing the right sensor location to determine the core body temperature is a particular matter of academic and clinical debate. This study aimed to investigate the relationship of measured temperatures at different sites during surgery in deep hypothermic patients. METHODS In this prospective single-centre study, we studied 24 ...

S ystemic amyloidosis is a relatively rare multisystem disease caused by the deposition of misfolded protein in various tissues and organs. It may present to almost any specialty, and diagnosis is frequently delayed.1 Cardiac involvement is a leading cause of morbidity and mortality, especially in primary light chain (AL) amyloidosis and in both wild-type and hereditary transthyretin amyloidosi...

Background. Systemic amyloidosis is a potentially fatal condition, unless diagnosed and treated before development of irreversible organ damage. Demonstration of amyloid deposits within tissue biopsies is only definitive diagnostic method, which makes appropriate selection of biopsy site essential. Herein, we evaluated efficacy of minimally invasive minor salivary gland biopsy (MSGB) for the di...