Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed by an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl-metal species, which then rearranges selectively by careful choice of cat...

GENERIC NAME PAGE Carbamazepine 378 Clobazam 381 Clonazepam 380 Clorazepate 381 Diazepam 383 Ethosuximide 381 Ethotoin 378 Felbamate 382 Fosphenytoin 383 Gabapentin 382 Levetiracetam 382 Lamotrigine 379 Lorazepam 380 GENERIC NAME PAGE Mephenytoin 378 Mephobarbital 381 Metharbital 381 Nitrazepam 381 Oxcarbazepine 379 Phenobarbital 381 Phenytoin 377 Primidone 381 Tiagabine 381 Topiramate 379 Valp...

BACKGROUND AND PURPOSE Discrete focal lesions in the splenium of the corpus callosum on MR images in epileptic patients have received little attention in the literature. Our purpose was to describe these lesions, which may be related to the toxicity of antiepileptic drugs (AEDs), and to discuss the possible mechanisms of their development. METHODS We examined six patients with epilepsy whose ...

We report two cases with complex partial and secondarily generalized seizures, both on oxcarbazepine and vigabatrin, with additional lamotrigine in one case. Both died in a manner resembling SUDEP, i.e. suddenly, unexpectedly, probably following a seizure with pulmonary oedema at autopsy. Both had SIADH. A number of drugs may cause SIADH, among them carbamazepine and oxcarbazepine. A search for...