1 Goal SPEM (S-system Parameter Estimation Method) package allows for the computation of parameters in the n-gene S-system from time series data. 2 Introduction Biological systems are composed of interacting components [1]. The process of the expression and the interactions of these components are nonlinear. S-systems have a power law formalism which is general enough to capture the base of the...

Gelastic seizures, characterized by epileptic laughter, are rare and the majority is associated with hypothalamic hamartomas. We report a case with cryptogenic Gelastic seizure (without hypothalamic hamartoma), as the MRI was normal and, EEG and clinical data suggested a focal origin of the seizures.

1 Abstract Although the smartphone has emerged as the most convenient device on which to capture photos, it lacks the tools to effectively view and organize these photos. Given the casual nature of smartphone photography, we propose a system that can streamline and simplify the post-capture process. We propose Vignette, a content management system for smartphone photography that improves the vi...

What are Hereditary Ataxias? Ataxia is a neurologic disorder in which there is loss of coordination of movement. It can result from dysfunction of the cerebellum and brain stem and their afferent or efferent pathways. The etiology of ataxia can be divided into 3 main categories: acquired, sporadic, and hereditary. Hereditary ataxias are one of the largest groups of hereditary progressive neurod...

3 An example of workflow 2 3.1 Loading data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3.2 Data preprocessing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3.3 Differential statistical analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.3.1 Site level...

Usually, principal components analysis is carried out by calculating the eigenvalues and eigenvectors of the correlation matrix. With N cases and P variables, if we write X for the N × P matrix which has been standardised so that columns have zero mean and unit standard deviation, we find the eigenvalues and eigenvectors of the P × P matrix X.X (which is N or (N − 1) times the correlation matri...

Catch data from a single year across many cohorts of fish will be identical to longitudinal data of a single cohort if each cohort sampled began with the same number of fish (i.e., recruitment is constant) and if the mortality rate is constant across all ages and years. For example, the catches-at-age of the hypothetical 2002 and 2006 cohorts is shown on diagonals in Table 1 and are equal to th...

General George S. Patton Jr. died as the result of quadriplegia sustained in a car crash in Germany in 1945. His x-ray films revealed a fractured C-3 vertebra and a posterior dislocation of C-4 on C-5. The likely cause of death was a pulmonary embolus. Details of his medical treatment are reviewed and compared with therapies that a patient with a similar injury would receive today.

External hernia is one of the commonest causes of intestinal obstruction. Femoral hernia is a relatively uncommon hernia. It has a very high complication rate due to delayed diagnosis caused by deceptive symptomatology and subtle signs. CT scan enables a prompt diagnosis. Rigorous resuscitation followed by prompt surgical intervention is the mainstay of treatment. A case of a strangulated femor...

Quantile regression is an evolving body of statistical methods for estimating and drawing inferences about conditional quantile functions. An implementation of these methods in the R language is available in the package quantreg. This vignette offers a brief tutorial introduction to the package. R and the package quantreg are open-source software projects and can be freely downloaded from CRAN:...