Blocking cell division through the inhibition of mitosis is one of the most successful clinical strategies for the treatment of cancer. Taxanes and vinca alkaloids are in widespread use and have demonstrated substantive therapeutic efficacy. Both classes of compounds bind directly to tubulin, a structural component of the mitotic spindle. The ubiquitous utilization of tubulin in cell division i...

Increased abundance of βII- and βIII-tubulin isotypes in cancer cells confers resistance to vinca and taxoid site drugs; however, the role of these isotypes in the acquired resistance of cancer cells to non-vinca or non-taxoid site binding agents has not been described. Peloruside A (PLA) and laulimalide are the only known non-taxoid site microtubule-stabilizing agents. A human ovarian cancer c...

Vincristine, an alkaloid of periwinkle plant (vinca) used in the treatment of various malignancies. The experimental group included 36 male wistar albino rats. The animals were divided into four groups of nine animals each. The animals received same dose of vincristine 1 mg/kg b.w. given intragastrically through a ne rubber catheter reaching lower third of oesophagus. Equal number of controls ...

We demonstrate the presence of animal personality in an inter-tidal gastropod, Littorina littorea, both in a sample of individuals infected by the trematode Cryptocotyle lingua and in an uninfected sample. On average infected individuals behaved more cautiously than individuals free of infection, but the parasite did not affect repeatability. Although the parasite is not associated with greater...

An experiment to study the feasibility of intercropping the short duration agronomical crops in periwinkle was conducted at Nagarjun Medicinal Plants Garden, P.K.V. Akola during 1988 - 89, 89 - 90 and 90 - 91. The highest monetary return of Rs. 15,604/ per hectare was obtained from an intercropping system of periwinkle and groundnut is row proportion of 2:1.