The present study evaluated the hypothesis that the effects of hypoxia on sheep pregnancies at high altitude (HA) are mediated by oxidative stress and that antioxidant vitamins may prevent these effects. Both HA native and newcomer ewes were maintained at an altitude of 3,589 m during mating and pregnancy. Control low altitude (LA) native ewes were maintained at sea level. Half of each group re...

BACKGROUND Migraine is a prevalent and debilitating disease that may, in part, arise because of disruption in neurovascular endothelia caused by elevated homocysteine. This study examined the homocysteine-lowering effects of vitamin supplementation on migraine disability, frequency and severity and whether MTHFRC677T genotype influenced treatment response. METHODS This was a randomized, doubl...

ABSTRACT The effects of vitamins E and C supplementation on growth performance biochemical haematological parameters Japanese quail were studied. A total 360 one-day-old female quails randomly allocated to nine dietary treatment groups (10 birds per replicate 4 replicates treatment), including a control (basal diet) the basal diet supplemented with: 250 or 500 mg/kg vitamin C, E, both C. Vitami...

BACKGROUND AND PURPOSE Epidemiological studies have associated increased dietary intake of antioxidants (vitamin C, E, and beta-carotene) in preventing and decreasing the extent of ischemic brain injury. The effect of vitamin C supplementation on functional recovery after stroke has not been studied. METHOD In this retrospective, case-control study of 23 patients with ischemic stroke taking v...

BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

to investigate the effect of vitamin e supplementation on the response of intercellular adhesion molecule-1 (icam-1) to exhaustive exercise, 16 active men were selected and divided into supplementation and placebo groups based on vo2max. the subjects in each group completed 65 minutes of exhaustive exercise after14 days of supplementation. blood samples were collected before supplementation and...

Background Although several studies confirmed positive effects of fish oil on semen quality, the antioxidant status in omega-3 supplemented diets of several studies is a fuzzy point. The aim of this study was to investigate the effect of dietary fish oil and (or) vitamin E supplementation on cryopreserved sperm in Mehraban rams. MaterialsAndMethods Sixteen fertile rams were randomly allotted to...

One third of older people in nursing and/or residential homes have significant symptoms of depression. In younger people, deficiencies in selenium, vitamin C and folate are associated with depression. This study examines the association between micronutrient status and mood before and after supplementation. The objective was to determine whether the administration of selenium, vitamin C and fol...

BACKGROUND Cardiovascular factors are associated with cognitive decline. Antioxidants may be beneficial. METHODS AND RESULTS The Women's Antioxidant Cardiovascular Study was a trial of vitamin E (402 mg every other day), beta carotene (50 mg every other day), and vitamin C (500 mg daily) for the secondary prevention of cardiovascular disease. From 1995 to 1996, women > or =40 years of age wit...

Objective(s) Cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. This study was performed to determine the effect of daily supplementation of vitamin E on oocytes apoptosis in nicotine-treated mice. Materials and Methods In this experimental study, 24 NMARI adult female mice were randomly allocated into four experimental groups. ...