teachers’ sense of efficacy belief has been introduced as a context-specific construct, but the related literature is not clear on this specificity. this study was an attempt to show how contextual factors influence efficacy beliefs among english language teachers. to this end, thirty iranian efl teachers working in both school and private institute contexts were chosen as the participants to r...

The global high prevalence of diabetes mellitus has resulted into the development several oral hypoglycemic agents. However, these drugs have limited efficacy and harmful side effects, which call for search alternatives from natural sources. inhibition dipeptidyl peptidase-4 (DPP-4) activity increases level glucagon-like peptide-1 glucose-dependent insulinotropic polypeptide, in turn reduces hy...

Abstract Chimeric antigen receptor (CAR)-T cell therapy is a promising treatment for lymphoblastic leukemia and lymphoma. Despite initial response to CAR-T therapy, about 40% of patients relapse. Modulating metabolism (immunometabolism) being considering as novel approach improve efficacy. We have identified MCJ (DnaJC15) target enhance mitochondrial metabolism. an endogenous negative regulator...

An experimental study has been performed to compare the in vitro activity and the in vivo efficacy of tachyplesin III, colistin, and imipenem against a multiresistant Pseudomonas aeruginosa strain. In vitro experiments included MIC determination, time-kill, and synergy studies. For in vivo studies, a mouse model of sepsis has been used. The main outcome measures were bacterial lethality, quanti...

cutaneous leishmaniasis is endemic in 88 different countries. there are an estimated 1.5 million new cases each year, with over 90% occurring in afghanistan, algeria, iran, iraq, saudi arabia, syria (old world) and in brazil and peru (new world). miltefosine is effective in vitro and in vivo against leishmania species and it was demonstrated efficacy in animals via the oral route. this study is...

abstract aim and background: establishing and maintaining family and prevention of family breakdown involves having certain abilities and skills. the aim of the present study was to evaluate the role of different dimensions of spirituality and forgiveness as predictors of family efficacy. methods and materials: a correlational method was employed and the following measures were administered to ...

BACKGROUND/AIMS Many anti-fibrotic drugs with high in vitro efficacies fail to produce significant effects in vivo. The aim of this work is to use a statistical approach to design a numerical predictor that correlates better with in vivo outcomes. METHODS High-content analysis (HCA) was performed with 49 drugs on hepatic stellate cells (HSCs) LX-2 stained with 10 fibrotic markers. ~0.3 billio...

Carbonic anhydrase IX (CAIX) is a tumor-specific protein that is upregulated during hypoxic conditions where it is involved in maintaining the pH balance. CAIX causes extracellular acidification, thereby limiting the uptake of weak basic chemotherapeutic agents, such as doxorubicin, and decreasing its efficacy. The aim of this study was to determine if doxorubicin efficacy can be increased when...

objective(s): the present day challenge is how to obtain germ cells from stem cells to treat patients with cancer and infertility. much more efforts have been made to develop a procedure for attaining germ cells in vitro. recently, human umbilical cord-derived mesenchymal stem cells (humscs) have been introduced with higher efficacy for differentiation. in this work, we tried to explore the eff...