BACKGROUND The rotational vestibulo-ocular reflex (rVOR) generates compensatory eye movements in response to rotational head accelerations. The velocity-storage mechanism (VSM), which is controlled by the vestibulo-cerebellar nodulus and uvula, determines the rVOR time constant. In healthy subjects, it has been suggested that self-motion perception in response to earth-vertical axis rotations d...

Vascular smooth muscle (VSM) maturation is developmentally regulated and differs between vascular beds. The maturation and contribution of VSM function to tissue blood flow and blood pressure regulation during early gestation are unknown. The carotid artery (CA) contributes to fetal cerebral blood flow regulation and well being. We studied CA VSM contractility, protein contents, and phenotype b...

Arterial stiffness, a major cardiovascular risk factor, develops within 2 months in mice fed a high-fat, high-sucrose (HFHS) diet, serving as a model of human metabolic syndrome, and it is associated with activation of proinflammatory and oxidant pathways in vascular smooth muscle (VSM) cells. Sirtuin-1 (SirT1) is an NAD(+)-dependent deacetylase regulated by the cellular metabolic status. Our g...

Ca2+ sensitization of vascular smooth muscle (VSM) contraction involves Rho-dependent and Rho-kinase-dependent suppression of myosin phosphatase activity. We previously demonstrated that excitatory agonists in fact induce activation of RhoA in VSM. In this study, we demonstrate a novel Ca2+-dependent mechanism for activating RhoA in rabbit aortic VSM. High KCl-induced membrane depolarization as...

CORSO, a coordination system for virtual shared memory, allows bindings to different programming languages. Currently C, C++, Java, VisualBasic, and Oracle’s Developer2000 are supported. We implement an Ada binding to CORSO, thus opening the area of virtual shared memory to the Ada world. Our Ada CORSO binding enhances Ada with transaction-oriented, fault-tolerant, distributed objects in a stra...

Vector-based information retrieval methods such as the vector space model (VSM), latent semantic indexing (LSI), and the generalized vector space model (GVSM) represent both queries and documents by high-dimensional vectors learned from analyzing a training corpus of text. VSM scales well to large collections, but cannot represent term–term correlations, which prevents it from being used in tra...

Although glucocorticoid (GC)-induced hypertension has commonly been attributed to promiscuous activation of the mineralocorticoid receptor by cortisol, thereby promoting excess reabsorption of sodium and water, numerous lines of evidence indicate that this is not the only or perhaps even the primary mechanism. GC induce a number of effects on vascular smooth muscle (VSM) in vitro that may be pe...

Tantangan yang dihadapi perusahaan di industri manufaktur saat ini adalah efektivitas biaya, lead time singkat, dan kualitas produk baik. Penelitian dilakukan atap metal memiliki banyak variasi bahan baku barang jadi. Perusahaan memproduksi sesuai pesanan kebutuhan pelanggan (job order). Penggunaan Metode Value Stream Mapping (VSM) dimulai dengan mengidentifikasi Stream, kemudian dilanjutkan pe...

Ovaj rad demonstrira primenu elemenata Lean filozofije na snimanje i analizu gubitaka u procesu reklamacije proizvoda otklanjanja kvara, primenom VSM metodologije. Data je mapa tok vrednosti za trenutno željeno stanje prijema reklamacija.