Recent studies suggest that a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor (mGluRs), mGluR5, termed 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (VU-29), potentiates mGluR5 responses by actions at a site that is overlapping with the binding site of 2-methyl-6-(phenylethynyl)pyridine (MPEP), a previously identified negative allosteric modulator of this re...

Hughlings Jackson was the first to demonstrate that paroxysmal deij vu (called by him 'reminiscence') is significantly related to disease of the temporosphenoidal region (Jackson, 1880, 1888; Jackson and Colman, 1898; Jackson and Purves-Stewart, 1899). Although he mentioned several cases of dieja vu with left-sided lesions (Jackson, 1888; Jackson and Colman, 1898) in his view the phenomenon ari...

In déjà vu, a phenomenological impression of familiarity for the current visual environment is experienced with a sense that it should in fact not feel familiar. The fleeting nature of this phenomenon in daily life, and the difficulty in developing experimental paradigms to elicit it, has hindered progress in understanding déjà vu. Some neurological patients with temporal-lobe epilepsy (TLE) co...