OBJECTIVE To systematically investigate the role of matrix metalloproteinase-2 (MMP2) tagging single nucleotide polymorphisms (SNPs) and promoter functional polymorphism in the development of nasal polyps in a Chinese population in Taiwan. DESIGN We conducted a case-control study in 136 cases of chronic rhinosinusitis with bilateral nasal polyps and 136 controls. Seventeen SNPs were selected,...

The approximate variance for the standardized measure of gametic linkage disequilibrium has been described. However, this approach assumes knowledge of the phase of double heterozygotes or Hardy-Weinberg equilibrium. Here we give the approximate variance for a composite measure of linkage disequilibrium which depends only on genotype frequencies. We show by simulation that this variance approxi...

Microsatellite genotyping from samples with varying quality can result in an uneven distribution of errors. Previous studies reporting error rates have focused on estimating the effects of both randomly distributed and locus-specific errors. Sample-specific errors, however, can also significantly affect results in population studies despite a large sample size. From two studies including six mi...

Abstract For unsaturated soils, Terzaghi’s effective stress $$\sigma = \sigma ^\mathrm{tot}- u$$ σ = tot - u has been generalized by Bishop to the form ^B \chi B χ</mml:mi...

Much forensic inference based upon DNA evidence is made assuming that the Hardy-Weinberg equilibrium (HWE) is valid for the genetic loci being used. Several statistical tests to detect and measure deviation from HWE have been devised, each having advantages and limitations. The limitations become more obvious when testing for deviation within multiallelic DNA loci is attempted. Here we present ...

Gout is a common form of inflammatory arthritis caused by crystallization acid uric in the joints. The development gout not only triggered environmental factors but also genetic variation individuals. In this study, association between SLC2A9 rs16890979 and was investigated. Total DNA extracted from 410 blood samples 163 patients 247 age-matched healthy controls. Genotypes were obtained using P...

CYP2C9 is a major P450 2C enzyme, which hydroxylates about 16% of drugs that are in current clinical use and contributes to the metabolism of a number of clinically important substrate drugs such as warfarin. Ethnic differences in the genetic variation of CYP2C9 have been reported, and might be related to the frequencies of adverse reactions to drugs metabolized by CYP2C9 in different ethnic gr...