The aim of this study was to investigate the process transfer of a commercially available product from the current batch fluid bed granulation and drying production method to an innovative continuously operating "from powder to tablet" production line using twin screw granulation as an intermediate granulation step. By monitoring process outcomes (torque, water temperature at the granulator jac...

• Granulation growth literature is reviewed to find solutions for size prediction. Two limiting cases granule are found and equations determined. Growth behaviour also derived by including consolidation behaviour. The prediction matches longstanding regime maps strongly. solution includes nucleation, growth, breakage in a continuous solution. Size control granulation of great importance yet oft...

The aim of this study was to evaluate the effect three coformers and five disintegrants in granulation formulation on dissociation cocrystal during process by monitoring wet with probe-type low-frequency Raman (LF-Raman) spectroscopy. As model cocrystals, paracetamol (APAP)-oxalic acid (OXA), APAP-maleic (MLA), APAP-trimethylglycine (TMG) were used. recipe containing cocrystals performed over t...

The objective of this study was three-fold; to investigate the different mechanisms of material exchange during the equilibrium phase of the granulation process and whether these mechanisms are consistent with the mechanisms described in the growth regime map, to study how material properties and process conditions affect these exchange mechanisms, and to correlate Stokes deformation number to ...