PURPOSE The purpose of this study was to examine the relationships between choriocapillaris (CC) and retinal pigment epithelial changes in age-related macular degeneration (AMD). Morphologic changes in the retinal pigment epithelium (RPE)/choriocapillaris complex were quantified in dry and wet forms of AMD, and the results were compared with those in aged control eyes without maculopathy. MET...

The macula or macula lutea (originally from Latin macula, “spot” and lutea, “yellow”) is an oval-shaped spot, five mm in diameter, located temporal to the optical nerve and near the centre of the human retina. Although it comprises only a small part of the retina, it is responsible for the sharp central vision and colour vision. Age-related macular degeneration (AMD) is a disease in which the n...

INTRODUCTION Age-related macular degeneration is a serious visual disorder of the central retina and was recently reported to be associated with genetic background. Here we describe a genetic link to early onset age-related macular degeneration in members of an Asian family. CASE PRESENTATION A 73-year-old Asian woman developed age-related macular degeneration in the fifth decade of her life ...

PURPOSE To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS A total of 660 men and women born in Sheffield, United Kingdom, between 1922 and 1930 and whose size at birth was available were traced and invited to take part in the study. Of these, 392 attended for ophthalmic examination. Age-relate...

PURPOSE To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) patients and to correlate their levels with clinical findings. METHODS Undiluted aqueous humor samples (100-200 μl) were obtained from 16 wet AMD eyes and 12 control eyes. Forty chemokines were measured using a multiplex method. A 6×6 mm area of the macular region ce...

abstract background: transpupillary thermotherapy is a new treatment for subfoveal choroidal neovascularization which needs further evaluation. this study was aimed to evaluate the efficacy of transpupillary thermotherapy on regression of occult subfoveal choroidal neovascularization with or without pigment epithelial detachment in patients with age-related macular degeneration. methods: in a c...

BACKGROUND The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT) and time domain stratus OCT (TD OCT) in evaluating macular morphology alterations in wet age-related macular degeneration (AMD). METHODS This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization seco...

Hereditary macular degeneration has a multifarious ophthalmoscopic appearance but is usually characterized by a sharply-defined, dense, homogenous, avascular disc resembling the intact yolk of a fried egg (Sorsby, I940; Fransois, I96I; Braley, I966). The appearance of the macula, however, may range from mild pigmentary degeneration to dense scarring with pigmentary hyperplasia. The clinical cou...

PURPOSE To determine the prevalence of early and late-stage age-related macular degeneration (ARMD) and its association with risk factors such as age, gender, smoking, body mass index, hypertension and diabetes history, cataracts and pseudophakia. DESIGN Population-based cross-sectional study in an elderly Japanese-Brazilian population from Londrina (Paraná, Brazil). METHODS The study inclu...

Objective: To study the effects of intravitreal anti-Vascular Endothelial Growth Factor (VEGF) therapy with Avastin for wet Age-Related Macular Degeneration (AMD) on Benign Prostatic Hyperplasia (BPH)-related symptoms. Methods: An exploratory trial was conducted from August 1, 2013 to February 1, 2014, that included 14 male patients previously diagnosed with BPH, who were aged between 59 and 69...