Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA damage response proteins to promote appropriate repair and long-range recombination. Aberrant processing of these breaks, however, results in decreased CSR and/or increased frequency of illegitimate recombination between the immunoglobuli...

OBJECTIVE To study the dynamics of childhood overweight and the influence of dietary intake on tracking of overweight. DESIGN AND SETTING A follow-up study conducted in China. SUBJECTS Ninety-five overweight children, 6-13 years old, identified from 1455 children at baseline, were followed over a 2-year period. METHODS Data on anthropometry and 3-day dietary intake were collected at basel...