Monocyte-derived dendritic cells (moDCs) dramatically increase in numbers upon infection and inflammation; accordingly, we found that this also occurs during allogeneic responses. Despite their prominence, how emergent moDCs and resident conventional DCs (cDCs) divide their labor as APCs remain undefined. Hence, we compared both direct and indirect presentation by murine moDCs versus cDCs. We f...

Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA damage response proteins to promote appropriate repair and long-range recombination. Aberrant processing of these breaks, however, results in decreased CSR and/or increased frequency of illegitimate recombination between the immunoglobuli...

OBJECTIVE To study the dynamics of childhood overweight and the influence of dietary intake on tracking of overweight. DESIGN AND SETTING A follow-up study conducted in China. SUBJECTS Ninety-five overweight children, 6-13 years old, identified from 1455 children at baseline, were followed over a 2-year period. METHODS Data on anthropometry and 3-day dietary intake were collected at basel...