Aims: The present research was done to evaluate the antioxidant activity of aqueous extract Withania somnifera (Ashwagandha) in equine. Herbal antioxidants have gained popularity due their potency and safety, oxidative stress is a condition that more prevalent horses performing physical activities.
 Methods: Twenty clinically healthy were selected equally divided into treatment control gro...

6-Hydroxydopamine (6-OHDA) is one of the most widely used rat models for Parkinson's disease. There is ample evidence in the literature that 6-OHDA elicits its toxic manifestations through oxidant stress. In the present study, we evaluated the anti-parkinsonian effects of Withania somnifera extract, which has been reported to have potent anti-oxidant, anti-peroxidative and free radical quenchin...

The immune system evolved to protect organisms from an infinite variety of disease-causing agents but to avoid harmful responses to self. However, such a powerf~l defense mechanism requires regulation. Immune regulation includes homeostatic and cellmediated targeted mechanisms to the activation, differentiation and function of antigen-triggered immuno-competent cells and irnmunoregulatory cells...

Background: In this open-label, randomized, balanced, two-treatment, two-sequence, two-period, crossover, single-dose oral comparative pharmacokinetics study, the pharmacokinetics, safety, and tolerability of test product ‘ashwagandha (Withania somnifera)’ root extract sustained release capsule 300 mg (Prolanza™), each containing 15 withanolides (administered dose: 2×15 mg) was compared with th...

The objective of the present study was to evaluate the antidepressant action of Withania somnifera (WS) as well as its interaction with the conventional antidepressant drugs and to delineate the possible mechanism of its antidepressant action using forced swimming model in mice. Effect of different doses of WS, fluoxetine and imipramine were studied on forced swimming test induced mean immobili...

The present study was aimed at documenting the detailed ethnomedicinal knowledge of an unexplored area of Pakistan. Semistructured interviews were taken with 55 informants randomly chosen regarding detailed ethnomedicinal and sociocultural information. The study exposed 67 medicinal plant species used to prepare 110 recipes and the major modes of herbal formulation were decoction and powdering ...

Withania somnifera (W. somnifera), a small, woody shrub in the Solanaceae family, has been studied using phytochemical test, antibacterial activity and partial characterizations. Air-dried powdered leaves of plant were extracted with maceration over an electrical shaker solvent chloroform methanol. After crude extracts concentrated, diffusion susceptibility test was carried out on 25, 50, 75, 1...

The herbal vendors are the mobile tribal medicinement seen on the busy streets of many Indian cities selling crude medicinal plants and their products. They prescribe herbal treatment for several diseases, a skill they inherited from their forefathers through several generations of experience. They claim to have specific herbal remedies for the complete cure of some urino - genital disorders su...