UNLABELLED Brain region-specific changes have been demonstrated with a variety of cognitive training interventions. The effect of cognitive training on brain subnetworks in humans, however, remains largely unknown, with studies limited to functional networks. Here, we used a well-established working memory training program and state-of-the art neuroimaging methods in 40 healthy adults (21 femal...

This paper gives a brief overview of phases in brain development and discusses the hypothesis that mechanisms of working memory development are partly the same as those of working memory training. Brain development could be related to different, but overlapping phases: (i) structural maturation, with a relatively high reliance of preprogrammed processes; (ii) interactive specialization, which i...

Rats exposed to 30 minutes of four-vessel occlusion reliably develop severe bilateral CA1 hippocampal injury; under certain conditions of radial maze training, such rats perform the reference memory component as well as controls yet perform the working memory component worse than controls. Reference memory is thought to depend on invariable and working memory on variable spatial information. We...

Since antiquity, philosophers, theologians, and scientists have been interested in human memory. However, researchers today are still working to understand the capabilities, boundaries, and architecture. While the storage capabilities of long-term memory are seemingly unlimited (Bahrick, J Exp Psychol 113:1-2, 1984), working memory, or the ability to maintain and manipulate information held in ...

The aim of this study was to design and to assess the effectiveness of a working memory (WM) intervention for deaf children. A review of factors that explain deaf students’ poor results in WM tasks was used to identify deaf participants' strengths and difficulties in WM tasks. This review formed the basis for the design of the WM training program assessed in the study. Participants were 77 chil...

Cognitive symptoms of depression, such as rumination, have shown to be associated with deficits in working memory functioning. More precisely, the capacity to expel irrelevant negative information from working memory seems to be affected. Even though these associations have repeatedly been demonstrated, the nature and causal direction of this association is still unclear. Therefore, within an e...

There is accumulating evidence that training working memory (WM) leads to beneficial effects in tasks that were not trained, but the mechanisms underlying this transfer remain elusive. Brain imaging can be a valuable method to gain insights into such mechanisms. Here, we discuss the impact of cognitive training on neural correlates with an emphasis on studies that implemented a WM intervention....

We piloted a computer program to train working memory for children with attention problems or hyperactivity who attended an urban public school serving economically disadvantaged neighborhoods. Training was conducted daily for 5 weeks during school hours. Teachers rated children’s behaviors before and after the intervention, and standardized assessments of verbal and visuo-spatial working memor...

Dopamine D1-like receptors consist of D1 (D1A) and D5 (D1B) receptors and play a key role in working memory. However, their possibly differential contribution to working memory is unclear. We combined a working memory training protocol with a stepwise increase of cognitive subcomponents and real-time RT-PCR analysis of dopamine receptor expression in pigeons to identify molecular changes that a...

OBJECTIVE The aim of this study was to examine the effects of Cogmed training on working memory in adults with ADHD, including the generalization of effects to nonverbal reasoning, executive function in daily life, and ADHD symptoms. METHOD Adults of ages 18 to 63 with ADHD were randomly assigned to an experimental group that received the working memory training or to a placebo group that rec...