Cytokines play important roles in the wound healing process through various signalling pathways. The JAK-STAT pathway is utilised by most cytokines for signal transduction and is regulated by a variety of molecules, including suppressor of cytokine signalling (SOCS) proteins. SOCS are associated with inflammatory diseases and have an impact on cytokines, growth factors and key cell types involv...

In this study it was determined i) whether an autologous skin substitute (SS) which heals chronic wounds could heal excision wounds, and ii) whether soluble proteins present in chronic and excision wound exudates might influence the potency of the SS and in turn the final outcome of wound healing. For clinical applications, SS were applied to tumor excision wounds. For mechanistic studies, SS c...

During the recent years several non-pharmaceutical treatments have been proposed as alternative or adjunctive treatment for chronic wounds. Low level laser therapy (LLLT) is a new technique used for the treatment of wounds. The present study reviews the most current laser radiation based methods for wound treatments and clinical considerations for the different wounds. In addition, the proposed...

Background Diabetes related foot ulcers (DRFU) frequently require surgical debridement or limb saving, partial foot amputation. The resultant wounds are generally deep and associated with prolonged healing times. Negative pressure wound therapy (NPWT) is increasingly used to facilitate healing of these complex wounds. This retrospective audit provides outcome data on patients with post-surgical...

PURPOSE To get the maximum benefit of vacuum-assisted closure (VAC) in the management of acute and chronic wounds without abuse or misuse. METHODS Fourty one patients were included in the study. Among them, 9 patients had chronic wounds and the rest 32 patients had acute wounds. In acute wounds, 19 patients had co-morbid conditions. Seven patients had gaped wounds, 4 patients had necrotizing ...

Chronic wounds are a significant socioeconomic problem for governments worldwide. Approximately 15% of people who suffer from diabetes will experience a lower-limb ulcer at some stage of their lives, and 24% of these wounds will ultimately result in amputation of the lower limb. Hyperbaric Oxygen Therapy (HBOT) has been shown to aid the healing of chronic wounds; however, the causal reasons for...

OBJECTIVE Our group has developed a bipolar bioimpedance measurement-based method for determining the state of wound healing. The objective of this study was to assess the capability of the method. METHODS To assess the performance of the method, we arranged a follow-up study of four acute wounds. The wounds were measured using the method and photographed throughout the healing process. RES...

A new technological approach for supplying hypoxic chronic wounds with oxygen is a moist wound treatment with aqueous solutions containing tissue compatible oxygen binders. This facilitates diffusion of oxygen, necessary for the healing process, from the surroundings (room air through an open-porous wound padding) into the ulcerous tissue. A product that is still in development is a spray which...

BACKGROUND Various studies have shown that phototherapy promotes the healing of cutaneous wounds. OBJECTIVE To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats. METHODS Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode tr...

The purpose of this article is to review literature related to hyperbaric oxygenation and wound healing. The article discusses the role of oxygen in wound healing, as well as the effects of hyperbaric oxygenation to promote wound healing, and focuses on the use of hyperbaric oxygenation to treat foot wounds in patients with diabetes. A review of salient literature to support the use of hyperbar...