Mutations in the XNP/ATR-X gene, located in Xq13.3, are associated with several X linked mental retardation syndromes, the best known being alpha thalassaemia with mental retardation (ATR-X). The XNP/ATR-X protein belongs to the family of SWI/SNF DNA helicases and contains three C2-C2 type zinc fingers of unknown function. Previous studies have shown that 65% of mutations of XNP have been found...

Proof. First, we show that F [x, y]/(y−x) ∼= F [t]. Let φ : F [x, y]→ F [t] be an homomorphism given by φ(x) = t, φ(y) = t and φ(f) = f (for all f ∈ F ). Note that the kernel of the homomorphism is precisely (y−x), therefore by the 1st isomorphism theorem F [x, y]/(y−x) ∼= F [t]. Furthermore since F [t] is an integral domain, so is F [x, y]/(y − x). Now, we will show that F [x, y]/(y − x) has z...

Let V (resp. D) be a valuation domain (resp. SFT Prüfer domain), I a proper ideal, and V̂ (resp. D̂) be the I-adic completion of V (resp. D). We show that (1) V̂ is a valuation domain, (2) Krull dimension of V̂ = dimV I+1 if I is not idempotent, V̂ ∼= V I if I is idempotent, (3) dim D̂ = dimD I + 1, (4) D̂ is an SFT Prüfer ring, and (5) D̂ is a catenarian ring. Throughout this paper, all rings are assu...

We investigate modal algebras that arise by adding operations of domain and antidomain to semirings and Kleene algebras. Let (S,+, ·, 0, 1) be a noncommutative and additively idempotent semiring with natural order defined as x ≤ y ⇔ x + y = x. Such semirings have many computational models, e.g., binary relations under union and relative product, languages, paths in graphs or program traces unde...

The 3'X domain of hepatitis C virus is a strongly conserved structure located at the 3' terminus of the viral genomic RNA. This domain modulates the replication and translation processes of the virus in conjunction with an upstream 5BSL3.2 stem-loop, and contains a palindromic sequence that facilitates RNA dimerization. Based on nuclear magnetic resonance spectroscopy and gel electrophoresis, w...

E-selectin elicits cell adhesion by binding to the cell surface carbohydrate, sialyl Lewis X (sLe(x)). We evaluated the effects of mutations in the E-selectin lectin domain on the binding of a panel of anti-E-selectin mAbs and on the recognition of immobilized sLe(x) glycolipid. Functional residues were then superimposed onto a three-dimensional model of the E-selectin lectin domain. This analy...